医学
地塞米松
安慰剂
麻醉
臂丛神经
前臂
臂丛神经阻滞
神经阻滞
上肢
外科
内科学
替代医学
病理
作者
Mathias Maagaard,Morten Plambech,Kamilia S. Funder,Nikolaj K. Schou,Asger M. Andreasen,Emma Ritsmer Stormholt,Morten Fiil Leth,Shaheer Bukhari,Alicja Mortensen,Troels Haxholdt Lunn,Ida Tryggedsson,Anders Kehlet Nørskov,Cyrus Zamany,Peter Toquer,Pia Jæger,Johan Hviid Andersen,Ole Mathiesen
出处
期刊:Anaesthesia
[Wiley]
日期:2023-10-21
卷期号:78 (12): 1465-1471
被引量:2
摘要
The effects of oral dexamethasone on peripheral nerve blocks have not been investigated. We randomly allocated adults scheduled for forearm or hand surgery to oral placebo (n = 61), dexamethasone 12 mg (n = 61) or dexamethasone 24 mg (n = 57) about 45 min before lateral infraclavicular block. Mean (SD) time until first pain after block were: 841 (327) min; 1171 (318) min; and 1256 (395) min, respectively. Mean (98.3%CI) differences in time until first postoperative pain for dexamethasone 24 mg vs. placebo and vs. dexamethasone 12 mg were: 412 (248-577) min, p < 0.001; and 85 (-78 to 249) min, p = 0.21, respectively. Mean (98.3%CI) difference in time until first postoperative pain for dexamethasone 12 mg vs. placebo was 330 (186-474) min, p < 0.001. Both 24 mg and 12 mg of oral dexamethasone increased the time until first postoperative pain compared with placebo in patients having upper limb surgery under infraclavicular brachial plexus block.
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