Effect of boric acid and quercetin combination on oxidative stress/ cognitive function in parkinson model

Parkinson's disease (PD) is a one of the important neurodegenerative disorders that affect dopaminergic neurons in the brain. Quercetin is one of the most potent antioxidants among all flavonoids, with direct radical scavenging activities and induction of antioxidative enzymes. Studies have shown that boric acid is essential for the activity of brain functions. We also used 3-month-old Wistar-albino male rats in our study, the experimental groups were divided into 8 groups (n=7) and Glutathione (GSH) and Malondialdehyde (MDA) levels were determined manually in brain tissue samples. Also, Total Antioxidant Status (TAS) was determined using a commercial kit. Locomotor Activity and Object Recognition tests were applied to evaluate the cognitive functions of the rats. GraphPad Prism 9 version was used for statistical analysis. Values were statistically analyzed by one-way ANOVA, differences between groups were determined using Uncorrected Fisher's LSD tests. p < 0.05 was considered statistically significant. In our study, we think that BA will positively affect the oxidant-antioxidant balance by preventing the pathogenesis of PD.