药代动力学
金黄色葡萄球菌
医学
头孢菌素
耐甲氧西林金黄色葡萄球菌
药理学
人口
微透析
抗生素
群体药代动力学
丸(消化)
脑膜炎
抗菌剂
微生物学
内科学
生物
外科
中枢神经系统
细菌
环境卫生
遗传学
作者
Victória Etges Helfer,Bruna Bernar Dias,Graziela de Araújo Lock,Caroline Andrade Tomaszewski,Lucas Suchecki Barnet,Fabiano Barreto,Alexandre Prehn Zavascki,Bibiana Verlindo de Araújo,Teresa Dalla Costa
摘要
A population pharmacokinetic model was developed to describe alterations in ceftaroline brain disposition caused by meningitis in healthy and methicillin-resistant Staphylococcus aureus (MRSA)-infected rats. Blood and brain microdialysate samples were obtained after a single bolus dose of ceftaroline fosamil (20 mg/kg) administered intravenously.
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