化学
多酚
超分子化学
葫芦素
有机化学
纳米技术
材料科学
分子
抗氧化剂
作者
Riku Kawasaki,Shogo Kawamura,Tomoki Kodama,Keita Yamana,Akira Maeda,Dilimulati Yimiti,Shigeru Miyaki,Shodai Hino,Naoki Ozawa,Tomoki Nishimura,Seiji Kawamoto,Atsushi Ikeda
标识
DOI:10.1002/mabi.202200462
摘要
The prevalence of allergic disorders has increased worldwide in recent decades. Polyphenols, including resveratrol and curcumin, are posited to have potential as therapeutic agents for allergy; however, their use has been limited by poor water solubility. Accordingly, a highly concentrated, water dispersible, supramolecular complexes of polyphenols with polypeptides (poly-L-lysine, poly-γ-glutamic acid) and gelatin using high-speed vibration milling are developed. The complex exhibits resistance to photobleaching and thermal radiation. Treatment of a rat basophilic leukemia cell line (RBL-2H3) with polypeptide complexes containing resveratrol is suppressed allergic responses in vitro. Moreover, aerosolized administration of polypeptide complexes demonstrates excellent bioavailability and inhibition of immediate hypersensitivity reactions in ear tissue in vivo. Furthermore, the method avoids the use of organic solvent and therefore reduces undesirable biological responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI