类黄酮生物合成
MYB公司
类黄酮
转录因子
生物
转录组
结构基因
抄写(语言学)
调节基因
基因
激活剂(遗传学)
发起人
转录调控
生物合成
生物化学
基因表达调控
基因表达
突变体
哲学
抗氧化剂
语言学
作者
Yan Zhao,Guanghui Zhang,Qingyan Tang,Wanling Song,Qingqing Gao,Guisheng Xiang,Xia Li,Guanze Liu,Wei Fan,Xiaoning Li,Sheng-Chao Yang,Chenxi Zhai
标识
DOI:10.3389/fpls.2022.946827
摘要
Erigeron breviscapus , a traditional Chinese medicinal plant, is enriched in flavonoids that are beneficial to human health. While we know that R2R3-MYB transcription factors (TFs) are crucial to flavonoid pathway, the transcriptional regulation of flavonoid biosynthesis in E. breviscapus has not been fully elucidated. Here, EbMYBP1 , a R2R3-MYB transcription factor, was uncovered as a regulator involved in the regulation of flavonoid accumulation. Transcriptome and metabolome analysis revealed that a large group of genes related to flavonoid biosynthesis were significantly changed, accompanied by significantly increased concentrations of the flavonoid in EbMYBP1- OE transgenic tobacco compared with the wild-type (WT). In vitro and in vivo investigations showed that EbMYBP1 participated in flavonoid biosynthesis, acting as a nucleus-localized transcriptional activator and activating the transcription of flavonoid-associated genes like FLS , F3H , CHS , and CHI by directly binding to their promoters. Collectively, these new findings are advancing our understanding of the transcriptional regulation that modulates the flavonoid biosynthesis.
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