Evidence for a causal association between psoriasis and psychiatric disorders using a bidirectional Mendelian randomization analysis in up to 902,341 individuals

孟德尔随机化 重性抑郁障碍 优势比 医学 双相情感障碍 银屑病 精神科 内科学 精神分裂症(面向对象编程) 心情 基因型 免疫学 遗传学 生物 基因 遗传变异
作者
Yujie Wang,Xinquan Wang,Xiaoyu Gu,Jie Pan,Zhen Ouyang,Wenrui Lin,Wu Zhu,Mi Wang,Juan Su
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:337: 27-36 被引量:14
标识
DOI:10.1016/j.jad.2023.05.059
摘要

The causal association between psoriasis and psychiatric disorders remains ambiguous.This study aimed to investigate the causal relationship between psoriasis and common psychiatric disorders using bidirectional Mendelian randomization (MR) analysis.Major depressive disorder (MDD) (N = 217,584), bipolar disorder (N = 51,710), schizophrenia (N = 77,096), and anxiety disorder (N = 218,792) were obtained as outcomes, and psoriasis (N = 337,159) were as exposure. Inverse variance weighting (IVW) was used as the main method, with other sensitivity methods as auxiliary methods. Sensitivity analysis and heterogeneity tests were performed to ensure the robustness of the results. We also performed a subgroup analysis of cases with psoriatic arthritis (PsA) (N = 213,879) by using the same testing methods.MR showed that the genetic risk of psoriasis was positively associated with bipolar disorder (odds ratio (OR) = 13.54, 95 % confidence interval (95%CI): 2.43-75.37, P = 0.002) and MDD (OR = 1.08, 95%CI: 1.01-1.15, P = 0.027), which indicated possible causal relationships between psoriasis and these two diseases. Schizophrenia (OR = 3.52, 95%CI: 0.22-55.71, P = 0.372) and anxiety disorders (OR = 0.65, 95%CI: 0.16-2.63, P = 0.546) indicated no significant causal association. No reverse causal effects of psychiatric disorders on psoriasis were found. Subgroup analysis also suggested causal association of PsA with the bipolar affective disorder (OR = 1.05, 95%CI: 1.01-1.08, P = 0.005).Potential pleiotropic effects, restriction to European populations, and differences in diagnostic criteria.This study has supported the causal association of psoriasis with MDD and bipolar disorder, and the subtype PsA with bipolar disorder, which informed the intervention for mental illnesses in patients with psoriasis.
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