Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis

炎症 骨关节炎 医学 滑膜炎 脂肪因子 趋化因子 软骨 关节炎 生物信息学 免疫学 内科学 病理 瘦素 生物 肥胖 替代医学 解剖
作者
A. De Roover,Ana Escribano-Núñez,S. Monteagudo,Rik Lories
出处
期刊:Osteoarthritis and Cartilage [Elsevier]
卷期号:31 (10): 1303-1311 被引量:32
标识
DOI:10.1016/j.joca.2023.06.005
摘要

Objectives As more has become known of the pathophysiology of osteoarthritis (OA), evidence that inflammation plays a critical role in its development and progression has accumulated. Here, we aim to review current knowledge of the complex inflammatory network in the OA joint. Design This narrative review is presented in three main sections: local inflammation, systemic inflammation, and therapeutic implications. We focused on inflammatory mediators and their link to OA structural changes in the joint. Results OA is characterized by chronic and low-grade inflammation mediated mostly by the innate immune system, which results in cartilage degradation, bone remodeling and synovial changes. Synovitis is regarded as an OA characteristic and associated with increased severity of symptoms and joint dysfunction. However, the articular cartilage and the subchondral bone also produce several pro-inflammatory mediators thus establishing a complex interplay between the different tissues of the joint. In addition, systemic low-grade inflammation induced by aging, obesity and metabolic syndrome can contribute to OA development and progression. The main inflammatory mediators associated with OA include cytokines, chemokines, growth factors, adipokines, and neuropeptides. Conclusions Future research is needed to deeper understand the molecular pathways mediating the inflammation in OA to provide new therapeutics that target these pathways, or to repurpose existing drugs.
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