核酸
生物传感器
化学
纳米技术
核酸检测
组合化学
共价键
生物化学
有机化学
材料科学
作者
Zi-Wei Yang,Jiajing Li,Yuhan Wang,Fu-Han Gao,Jing-Lian Su,Yang Liu,Huai‐Song Wang,Ya Ding
标识
DOI:10.1016/j.ccr.2023.215249
摘要
The detection of nucleic acid marker is essential for accurate and timely diagnosis and prognosis of different types of diseases. However, the sensitivity and specificity of the assay still need to be improved. Due to the highly ordered porous structure, adjustable pore size, and large specific surface area, metal/covalent-organic frameworks (MOFs/COFs) can construct multifunctional sensors, which show significant advantages of adsorption, fluorescence quenching/emission, and electrocatalysis in nucleic acid detection. This review provides an overview of the design and construction of biosensors using MOFs/COFs for nucleic acid detection. The interaction between MOFs/COFs and nucleic acids and the detection of ctDNAs, microRNAs, mRNAs, genes, and other nucleic acid molecules based on these biosensors have been comprehensively discussed. In addition, the successful cases proposed by our and other groups have been analyzed in detail. The focus is on the rational design of biosensors by taking advantage of the unique structures and optical properties of MOFs/COFs to improve the sensitivity and selectivity of nucleic acid detection. We hope that the perspectives and insights provided in this review will promote the exploration of further potential applications of MOFs and/or COFs in biomarker sensing and imaging.
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