Kawasaki Disease: 10-year Single-center Experience: Analysis of Clinical and Laboratory Findings with Treatment Approaches

Objective: Kawasaki disease (KD) is an acute febrile multisystem disease affecting children between 6 months and 5 years.Coronary artery involvement (CAI) is the most threatened complication of this disease.Therefore, suspicion and early diagnose of the disease is critical.Principal and additional findings are used for diagnosis accompanied by laboratory findings.We evaluated the patients who had the diagnosis and treated for KD at our center.Methods: Forty-five patients who were evaluated between 2012-2022 with the diagnosis of KD were evaluated retrospectively in our study.Intravenous immunoglobulin (IVIG) administration time, and presence of principal, and additional findings were recorded.Echocardiographic and laboratory findings were also recorded for the study.Results: Male patients were in predominace, average age was 2 years.Coronary artey involvement was present in 20% and IVIG resistance in 17.8% of the patients.Changes in the oral mucosa and lips were less frequent in the patients with CAI (+), and perineal desquamation was more frequent with IVIG resistance (p=0.039,p=0,033, respectively).All the patients were treated before 10 days (p>0.05) and a second dose of IVIG was administered to 2 patients on the 12 th day.Conclusion: KD should be considered for the patients with longlasting fever, which cannot be explained with other reasons in children under 5 years of age.The relationship between the principal and additional findings with the presence of CAI and IVIG resistance were not mentioned in the literature previously.The similarity of laboratory findings in the groups suggests that laboratory findings may not always guide us about the course of the disease.Although KD may have severe complications, with timely and accurate diagnosis and treatment, the prognosis is good in general.