脱发
化疗
间充质干细胞
医学
紫杉醇
头皮
间质细胞
外体
病理
癌症研究
微泡
内科学
外科
皮肤病科
生物
小RNA
生物化学
基因
作者
Amir Hossein Norooznezhad,Reza Yarani,Mehrdad Payandeh,Zohreh Hoseinkhani,Hamidreza Mahmoudi,Sara Kiani,Kamran Mansouri
出处
期刊:Heliyon
[Elsevier]
日期:2023-04-01
卷期号:9 (4): e15165-e15165
被引量:3
标识
DOI:10.1016/j.heliyon.2023.e15165
摘要
Cancer is among the leading causes of death worldwide and affects a considerable number of individuals. Chemotherapy is one the most common treatment for this condition and hair loss is among one of the most prevalent side effects. In this study, we report successful treatment of a patient suffering from persistent chemotherapy-induced alopecia (PCIA) with extracellular enriched vesicles (EVs) derived from human placental mesenchymal stromal cells (MSCs).The patient was a 36-year-old woman with a history of invasive ductal carcinoma, underwent six courses of chemotherapy with paclitaxel and adriamycin. Following this treatment and for almost 18 months, she, unfortunately, had no regrowth of hair except some light vellus hairs on the scalp. She then received MSC-derived EVs with scalp injection (subcutaneous) every 4 weeks for 3 continuous months at which point she presented complete regrowth of terminal hair on her scalp.This report demonstrates that MSC-derived EVs could be a possible treatment for permanent chemotherapy-induced alopecia; however, further studies and trials are necessary.
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