Plasma proteomics for risk prediction and identification of novel drug targets in systemic lupus erythematosus

蛋白质组学 药品 鉴定(生物学) 系统性红斑狼疮 医学 计算生物学 药理学 内科学 化学 疾病 生物 生物化学 植物 基因
作者
Sisi Yang,Yuanyuan Zhang,Ziliang Ye,Yanjun Zhang,Xiaoqin Gan,Yu Huang,Hao Xiang,Yiting Wu,Yiwei Zhang,Xianhui Qin
出处
期刊:Rheumatology [Oxford University Press]
标识
DOI:10.1093/rheumatology/keaf055
摘要

The relationship between proteomic profiles and incident systemic lupus erythematosus (SLE) remains unclear. We aimed to identify candidate plasma proteins for SLE risk in women, discover potential treatment targets for SLE, and develop and validate a protein-based prediction model for SLE risk. 28 220 women from the UK Biobank were randomly split into training (70%) and testing (30%) sets. During a median follow-up of 13.3 years, 90 and 38 SLE events occurred in the training and testing set, with an average onset age of 63 years. In the training set, a protein risk score for new-onset SLE was constructed using 22 out of 2,911 proteins. Of the 22 proteins, ITGAV, TNFRSF4, CXCL10 and CD207 were causally associated with SLE, and TNFRSF4 and CXCL10 have been developed as drug targets for cancer and autoimmune diabetes. The 22 proteins enriched in cytokine-cytokine receptor interaction, inflammatory, and immune response. TNF, CD80, and LGALS9 were key proteins within the protein network. In the testing set, the SLE protein risk score has a better predictive capability for new-onset SLE (C-index, 0.801; 95%CI, 0.715, 0.887) than clinical risk factors of SLE (C-index, 0.706; 95%CI, 0.612, 0.800) and polygenic risk score for SLE (C-index, 0.638; 95%CI, 0.555, 0.721). Adding SLE protein risk score to clinical risk factors of SLE (C-index from 0.706-0.827) improved the predictive performance. The SLE protein risk score had a good predictive performance for new-onset SLE in women. ITGAV, TNFRSF4, CXCL10 and CD207 were potential treatment targets for SLE.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
顺顺发布了新的文献求助20
1秒前
1秒前
1秒前
可爱的函函应助盼盼采纳,获得10
1秒前
hh发布了新的文献求助10
2秒前
2秒前
3秒前
烟花应助半糖采纳,获得10
3秒前
英姑应助Hh采纳,获得10
4秒前
5秒前
6秒前
七言山川完成签到,获得积分10
6秒前
小马甲应助11采纳,获得10
6秒前
lsy发布了新的文献求助10
7秒前
7秒前
7秒前
hj发布了新的文献求助10
7秒前
cora完成签到 ,获得积分20
7秒前
CipherSage应助zec200030采纳,获得10
8秒前
Meredith完成签到,获得积分10
8秒前
机灵柚子应助Gg121380采纳,获得10
8秒前
马克图布发布了新的文献求助10
8秒前
荷兰香猪完成签到,获得积分10
9秒前
zho发布了新的文献求助20
9秒前
10秒前
10秒前
淡定绾绾发布了新的文献求助10
11秒前
无花果应助mike采纳,获得10
11秒前
11秒前
鹏鱼晏组发布了新的文献求助10
12秒前
JEFFREYJIA发布了新的文献求助10
13秒前
李健应助阿通采纳,获得10
13秒前
13秒前
废寝忘食完成签到,获得积分20
13秒前
yoyofun应助专注邴采纳,获得10
14秒前
luisriley发布了新的文献求助10
14秒前
桐桐应助信仰g采纳,获得10
15秒前
MoXian完成签到,获得积分10
15秒前
周女士完成签到,获得积分10
16秒前
周志昂完成签到,获得积分10
16秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 720
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
有源雷达散射截面减缩——理论与应用 赫玛·辛格,拉凯什·莫汉·杰哈 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3569076
求助须知:如何正确求助?哪些是违规求助? 3140566
关于积分的说明 9437919
捐赠科研通 2841515
什么是DOI,文献DOI怎么找? 1561715
邀请新用户注册赠送积分活动 730628
科研通“疑难数据库(出版商)”最低求助积分说明 718167