Upregulation of CRISP3 and its clinical values in adult sepsis: a comprehensive analysis based on microarrays and a two-retrospective-cohort study

败血症 降钙素原 医学 生物标志物 回顾性队列研究 内科学 队列 入射(几何) 胃肠病学 生物 生物化学 光学 物理
作者
Anqiang Zhang,Dalin Wen,Xinxin Ma,Fei Zhang,Guo-sheng Chen,Kelimu Maimaiti,Gang Xu,Jianxin Jiang,Hongxiang Lu
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:15
标识
DOI:10.3389/fimmu.2024.1492538
摘要

Background Current lines of evidence indicate that cysteine-rich secretory protein 3 (CRISP3) is an immunoregulatory factor. Nevertheless, no study has explored the relationships between the values of CRISP3 and sepsis. Methods We conducted a comprehensive literature search and meta-analysis from the Gene Expression Omnibus (GEO) and ArrayExpress to determine the expression of CRISP3 in sepsis patients. Then, we explored whether plasma CRISP3 could serve as a potential biomarker to predict the risk of sepsis via two retrospective trauma cohorts. We evaluated the prediction power using the area under the curve (AUC). Results A total of 23 datasets were recruited for the comprehensive meta-analysis, and the combined standardized mean difference (SMD) of CRISP3 was 0.90 (0.50–1.30) (p < 0.001), suggesting that CRISP3 was overexpressed in sepsis patients. Meanwhile, sepsis patients had higher CRISP3 concentrations than non-sepsis patients in 54 trauma patients (p < 0.001). Plasma CRISP3 on admission was significantly associated with the incidence of sepsis [OR = 1.004 (1.002–1.006), p < 0.001]. As a predictive biomarker, CRISP3 obtained a better AUC [0.811 (0.681–0.905)] than C-reactive protein (CRP) [0.605 (0.463–0.735)], procalcitonin (PCT) [0.554 (0.412–0.689)], and Sequential Organ Failure Assessment (SOFA) [0.754 (0.618–0.861)]. Additionally, the clinical relationships between plasma CRISP3 and sepsis were verified in another trauma cohort with 166 patients [OR = 1.002 (1.001–1.003), p < 0.001]. The AUC of CRISP3 was 0.772 (0.701–0.834), which was better than that of CRP [0.521 (0.442–0.599)] and PCT [0.531 (0.452–0.609)], but not SOFA [0.791 (0.717–0.853)]. Conclusion Our study indicated and validated that CRISP3 was highly expressed in sepsis. More importantly, CRISP3 may serve as a latent biomarker to predict the risk of sepsis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
一瓶水发布了新的文献求助10
1秒前
橙子发布了新的文献求助10
1秒前
乐乐发布了新的文献求助20
2秒前
未来发布了新的文献求助10
2秒前
lalafish发布了新的文献求助10
3秒前
oyxz完成签到,获得积分10
3秒前
柔弱小之发布了新的文献求助10
3秒前
4秒前
Chemistry完成签到,获得积分10
4秒前
4秒前
niu发布了新的文献求助10
5秒前
简单的钢铁侠完成签到,获得积分10
5秒前
赘婿应助Demonmaster采纳,获得10
5秒前
张通发布了新的文献求助10
6秒前
拜拜拜仁完成签到,获得积分10
6秒前
6秒前
7秒前
7秒前
8秒前
8秒前
鱼儿会飞发布了新的文献求助10
8秒前
9秒前
七七发布了新的文献求助10
9秒前
9秒前
9秒前
小马过河发布了新的文献求助10
9秒前
大模型应助饱满的鑫采纳,获得10
10秒前
rong发布了新的文献求助10
10秒前
10秒前
10秒前
xiaofan发布了新的文献求助10
10秒前
Charming完成签到,获得积分10
11秒前
LLL发布了新的文献求助10
11秒前
李兴完成签到 ,获得积分10
11秒前
研友_8RlQ2n完成签到,获得积分10
11秒前
11秒前
11秒前
11秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3986829
求助须知:如何正确求助?哪些是违规求助? 3529292
关于积分的说明 11244137
捐赠科研通 3267685
什么是DOI,文献DOI怎么找? 1803843
邀请新用户注册赠送积分活动 881223
科研通“疑难数据库(出版商)”最低求助积分说明 808600