Efficacy of Natural Products as Tyrosinase Inhibitors in Hyperpigmentation Therapy: Anti‐Melanogenic or Antibrowning Effects

Hyperpigmentation in human skin and enzymatic browning are prevalent and undesirable phenomena. Tyrosinase, the principal enzyme implicated in these processes, is recognized for its crucial role in melanogenesis and browning reactions. This has spurred extensive research aimed at identifying, isolating, and characterizing novel and potent tyrosinase inhibitors for applications in the food, cosmetics, and pharmaceutical industries. Although significant progress has been made in the development of tyrosinase inhibitors, concerns regarding their safety persist due to potential adverse effects. Ongoing research is focused on identifying effective and safe candidates for tyrosinase inhibition derived from medicinal plants. So, this review focuses on the diverse range of tyrosinase inhibitors from natural sources. To date, numerous natural inhibitors have been identified through various screening techniques. Polyphenols and stilbenes have been recognized as the most effective classes of compounds as tyrosinase inhibitors. Till now, only a limited number of these inhibitors have been deemed suitable for clinical use as skin‐whitening agents. The insights presented in this review will offer a fresh perspective for advancing research aimed at developing safe and effective tyrosinase inhibitors derived from medicinal plants.