Glucagon-Like Peptide 1–Based Therapies and Risk of Pancreatic Cancer in Patients With Diabetes and Obesity

医学 胰腺癌 糖尿病 胰高血糖素样肽-1 肥胖 内科学 内分泌学 肿瘤科 癌症 2型糖尿病
作者
Arunkumar Krishnan,Yousaf Hadi,William R. Hutson,Shyam Thakkar,Shailendra Pratap Singh
出处
期刊:Pancreas [Lippincott Williams & Wilkins]
卷期号:51 (10): 1398-1403 被引量:3
标识
DOI:10.1097/mpa.0000000000002197
摘要

There have been conflicting reports concerning an increased risk of pancreatic cancer (PC) in new users of glucagon-like peptide-1 agonists (GLP-1As). We aimed to explore whether the use of GLP-1A is associated with an increased risk of PC.A multicenter, retrospective cohort study was conducted using TriNetX. Adult patients with diabetes and/or overweight and obesity who were newly treated with GLP-1A or metformin for the first time between 2006 and 2021 were matched 1:1 using propensity score matching. The risk of PC was estimated using a Cox proportional hazards model.A total of 492,760 patients were identified in the GLP-1A and 918,711 patients in the metformin group. After propensity score matching, both cohorts (370,490 each) were well matched. During follow-up, 351 patients in the GLP-1A and 956 on metformin developed PC after an exposure lag of 1 year. Glucagon-like peptide-1 agonists was associated with a significantly lower risk of PC (hazard ratio, 0.47; 95% confidence interval, 0.42-0.52).The use of GLP-1A in patients with obesity/diabetes is associated with a lower risk of PC compared with a similar cohort of patients using metformin. Our study findings reassure clinicians and patients with apprehensions about any possible association between GLP-1A and PC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
luoshikun发布了新的文献求助10
刚刚
烟花应助c57采纳,获得10
1秒前
喜喵喵发布了新的文献求助30
1秒前
纪富完成签到 ,获得积分10
1秒前
深情安青应助知性的雪糕采纳,获得10
1秒前
小白白发布了新的文献求助10
2秒前
虚幻的莞完成签到,获得积分10
3秒前
Sihan完成签到,获得积分10
4秒前
OULA!发布了新的文献求助20
5秒前
科研通AI5应助hh采纳,获得10
8秒前
8秒前
8秒前
0526Test发布了新的文献求助10
9秒前
Lucas应助清逸采纳,获得10
9秒前
Duduk完成签到,获得积分10
9秒前
10秒前
11秒前
12秒前
852应助OULA!采纳,获得10
14秒前
极大张希希完成签到 ,获得积分10
15秒前
15秒前
Akim应助王染墨采纳,获得10
16秒前
Niu发布了新的文献求助10
18秒前
19秒前
19秒前
深情安青应助zz采纳,获得10
20秒前
滑步小镰刀完成签到,获得积分20
21秒前
23秒前
23秒前
24秒前
24秒前
阡陌完成签到 ,获得积分10
24秒前
脑洞疼应助TK采纳,获得10
25秒前
邢文瑞发布了新的文献求助30
25秒前
李某发布了新的文献求助10
26秒前
Broadway Zhang完成签到,获得积分10
26秒前
小小完成签到,获得积分10
26秒前
27秒前
OULA!发布了新的文献求助10
27秒前
学术拉机发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976126
求助须知:如何正确求助?哪些是违规求助? 3520340
关于积分的说明 11202586
捐赠科研通 3256847
什么是DOI,文献DOI怎么找? 1798509
邀请新用户注册赠送积分活动 877645
科研通“疑难数据库(出版商)”最低求助积分说明 806516