Glucagon-Like Peptide 1–Based Therapies and Risk of Pancreatic Cancer in Patients With Diabetes and Obesity

医学 胰腺癌 糖尿病 胰高血糖素样肽-1 肥胖 内科学 内分泌学 肿瘤科 癌症 2型糖尿病
作者
Arunkumar Krishnan,Yousaf Hadi,William R. Hutson,Shyam Thakkar,Shailendra Pratap Singh
出处
期刊:Pancreas [Lippincott Williams & Wilkins]
卷期号:51 (10): 1398-1403 被引量:3
标识
DOI:10.1097/mpa.0000000000002197
摘要

There have been conflicting reports concerning an increased risk of pancreatic cancer (PC) in new users of glucagon-like peptide-1 agonists (GLP-1As). We aimed to explore whether the use of GLP-1A is associated with an increased risk of PC.A multicenter, retrospective cohort study was conducted using TriNetX. Adult patients with diabetes and/or overweight and obesity who were newly treated with GLP-1A or metformin for the first time between 2006 and 2021 were matched 1:1 using propensity score matching. The risk of PC was estimated using a Cox proportional hazards model.A total of 492,760 patients were identified in the GLP-1A and 918,711 patients in the metformin group. After propensity score matching, both cohorts (370,490 each) were well matched. During follow-up, 351 patients in the GLP-1A and 956 on metformin developed PC after an exposure lag of 1 year. Glucagon-like peptide-1 agonists was associated with a significantly lower risk of PC (hazard ratio, 0.47; 95% confidence interval, 0.42-0.52).The use of GLP-1A in patients with obesity/diabetes is associated with a lower risk of PC compared with a similar cohort of patients using metformin. Our study findings reassure clinicians and patients with apprehensions about any possible association between GLP-1A and PC.
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