射血分数保留的心力衰竭
心力衰竭
医学
观察研究
射血分数
背景(考古学)
随机对照试验
重症监护医学
心脏病学
人口
内科学
临床试验
古生物学
环境卫生
生物
作者
Akshay S. Desai,Carolyn S.P. Lam,John J.V. McMurray,Margaret M. Redfield
标识
DOI:10.1016/j.jchf.2023.03.011
摘要
Although patients with heart failure with preserved ejection fraction (HFpEF) (left ventricular ejection fraction ≥50%) comprise nearly half of those with chronic heart failure, evidence-based treatment options for this population have historically been limited. Recently, however, emerging data from prospective, randomized trials enrolling patients with HFpEF have greatly altered the range of pharmacologic options to modify disease progression in selected patients with HFpEF. In the context of this evolving landscape, clinicians are increasingly in need of practical guidance regarding the best approach to management of this growing population. In this review, the authors build on the recently published heart failure guidelines by integrating contemporary data from recent randomized trials to provide a contemporary framework for diagnosis and evidence-based treatment of patients with HFpEF. Where gaps in knowledge persist, the authors provide "best available" data from post hoc analyses of clinical trials or data from observational studies to guide management until more definitive studies are available.
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