细菌
鼠李糖
多糖
肽聚糖
化学
生物活性
免疫系统
生物化学
体外
细胞因子
微生物学
生物
酶
免疫学
遗传学
作者
Katarzyna Pacyga-Prus,Dominika Jakubczyk,Corine Sandström,Dagmar Šrůtková,Marcelina Pyclik,Katarzyna Leszczyńska,Jarosław Ciekot,Agnieszka Razim,Martin Schwarzer,Sabina Górska
标识
DOI:10.1016/j.carbpol.2023.120980
摘要
Bifidobacteria are among the most common bacteria used for their probiotic properties and their impact on the maturation and function of the immune system has been well-described. Recently, scientific interest is shifting from live bacteria to defined bacteria-derived biologically active molecules. Their greatest advantage over probiotics is the defined structure and the effect independent of the viability status of the bacteria. Here, we aim to characterize Bifidobacterium adolescentis CCDM 368 surface antigens that include polysaccharides (PSs), lipoteichoic acids (LTAs), and peptidoglycan (PG). Among them, Bad368.1 PS was observed to modulate OVA-induced cytokine production in cells isolated from OVA-sensitized mice by increasing the production of Th1-related IFN-γ and inhibition of Th2-related IL-5 and IL-13 cytokines (in vitro). Moreover, Bad368.1 PS (BAP1) is efficiently engulfed and transferred between epithelial and dendritic cells. Therefore, we propose that the Bad368.1 PS (BAP1) can be used for the modulation of allergic diseases in humans. Structural studies revealed that Bad368.1 PS has an average molecular mass of approximately 9,99 × 106 Da and it consists of glucose, galactose, and rhamnose residues that are creating the following repeating unit: →2)‐β‐D‐Glcp‐1→3‐β‐L‐Rhap‐1→4‐β‐D‐Glcp‐1→3‐α‐L‐Rhap‐1→4‐β‐D‐Glcp‐1→3‐α‐D‐Galp‐(1→n
科研通智能强力驱动
Strongly Powered by AbleSci AI