Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes

医学 肾功能 蛋白尿 肌酐 内科学 心力衰竭 急性肾损伤 心脏病学 风险因素 比例危险模型 队列 泌尿科
作者
Ian E. McCoy,Jesse Y. Hsu,Xiaoming Zhang,Clarissa J. Diamantidis,Jonathan J. Taliercio,Alan S. Go,Kathleen D. Liu,Paul E. Drawz,Anand Srivastava,Edward Horwitz,Jiang He,Jing Chen,James P. Lash,Matthew R. Weir,Chi‐yuan Hsu
出处
期刊:Clinical Journal of The American Society of Nephrology [Lippincott Williams & Wilkins]
卷期号:18 (7): 850-857 被引量:1
标识
DOI:10.2215/cjn.0000000000000163
摘要

Background Patients hospitalized with AKI have higher subsequent risks of heart failure, atherosclerotic cardiovascular events, and mortality than their counterparts without AKI, but these higher risks may be due to differences in prehospitalization patient characteristics, including the baseline level of estimated glomerular filtration rate (eGFR), the rate of prior eGFR decline, and the proteinuria level, rather than AKI itself. Methods Among 2177 adult participants in the Chronic Renal Insufficiency Cohort study who were hospitalized in 2013–2019, we compared subsequent risks of heart failure, atherosclerotic cardiovascular events, and mortality between those with serum creatinine–based AKI (495 patients) and those without AKI (1682 patients). We report both crude associations and associations sequentially adjusted for prehospitalization characteristics including eGFR, eGFR slope, and urine protein-creatinine ratio (UPCR). Results Compared with patients hospitalized without AKI, those with hospitalized AKI had lower eGFR prehospitalization (42 versus 49 ml/min per 1.73 m 2 ), faster chronic loss of eGFR prehospitalization (−0.84 versus −0.51 ml/min per 1.73 m 2 per year), and more proteinuria prehospitalization (UPCR 0.28 versus 0.16 g/g); they also had higher prehospitalization systolic BP (130 versus 127 mm Hg; P < 0.01 for all comparisons). Adjustment for prehospitalization patient characteristics attenuated associations between AKI and all three outcomes, but AKI remained an independent risk factor. Attenuation of risk was similar after adjustment for absolute eGFR, eGFR slope, or proteinuria, individually or in combination. Conclusions Prehospitalization variables including eGFR, eGFR slope, and proteinuria confounded associations between AKI and adverse cardiovascular outcomes, but these associations remained significant after adjusting for prehospitalization variables.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
CDKSEVEN完成签到,获得积分20
1秒前
量子星尘发布了新的文献求助10
1秒前
2秒前
zhuanghj5发布了新的文献求助10
3秒前
绵绵球发布了新的文献求助100
3秒前
3秒前
世界上最后一只呜呜怪完成签到,获得积分10
3秒前
cc2713206完成签到,获得积分0
4秒前
九月发布了新的文献求助10
4秒前
4秒前
Jasper应助北城采纳,获得10
6秒前
A阿澍发布了新的文献求助10
6秒前
顺利煎蛋完成签到,获得积分10
6秒前
肖肖发布了新的文献求助10
7秒前
chengmin完成签到 ,获得积分10
7秒前
wei发布了新的文献求助50
7秒前
8秒前
9秒前
sunwen发布了新的文献求助10
9秒前
10秒前
11秒前
北城完成签到,获得积分10
12秒前
十三完成签到 ,获得积分10
13秒前
打打应助傲寒采纳,获得10
13秒前
小李吃小孩完成签到,获得积分10
13秒前
含蓄大雁完成签到,获得积分10
13秒前
14秒前
Livrik发布了新的文献求助10
15秒前
卢敏明发布了新的文献求助10
15秒前
李健应助俏皮的白柏采纳,获得10
16秒前
16秒前
很好关注了科研通微信公众号
17秒前
17秒前
18秒前
研友_VZG7GZ应助九月采纳,获得10
19秒前
TTm关注了科研通微信公众号
19秒前
20秒前
20秒前
顾矜应助lixiaolu采纳,获得10
21秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035