Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes

医学 肾功能 蛋白尿 肌酐 内科学 心力衰竭 急性肾损伤 心脏病学 风险因素 比例危险模型 队列 泌尿科
作者
Ian E. McCoy,Jesse Y. Hsu,Xiaoming Zhang,Clarissa J. Diamantidis,Jonathan J. Taliercio,Alan S. Go,Kathleen D. Liu,Paul E. Drawz,Anand Srivastava,Edward Horwitz,Jiang He,Jing Chen,James P. Lash,Matthew R. Weir,Chi‐yuan Hsu
出处
期刊:Clinical Journal of The American Society of Nephrology [Lippincott Williams & Wilkins]
卷期号:18 (7): 850-857 被引量:1
标识
DOI:10.2215/cjn.0000000000000163
摘要

Background Patients hospitalized with AKI have higher subsequent risks of heart failure, atherosclerotic cardiovascular events, and mortality than their counterparts without AKI, but these higher risks may be due to differences in prehospitalization patient characteristics, including the baseline level of estimated glomerular filtration rate (eGFR), the rate of prior eGFR decline, and the proteinuria level, rather than AKI itself. Methods Among 2177 adult participants in the Chronic Renal Insufficiency Cohort study who were hospitalized in 2013–2019, we compared subsequent risks of heart failure, atherosclerotic cardiovascular events, and mortality between those with serum creatinine–based AKI (495 patients) and those without AKI (1682 patients). We report both crude associations and associations sequentially adjusted for prehospitalization characteristics including eGFR, eGFR slope, and urine protein-creatinine ratio (UPCR). Results Compared with patients hospitalized without AKI, those with hospitalized AKI had lower eGFR prehospitalization (42 versus 49 ml/min per 1.73 m 2 ), faster chronic loss of eGFR prehospitalization (−0.84 versus −0.51 ml/min per 1.73 m 2 per year), and more proteinuria prehospitalization (UPCR 0.28 versus 0.16 g/g); they also had higher prehospitalization systolic BP (130 versus 127 mm Hg; P < 0.01 for all comparisons). Adjustment for prehospitalization patient characteristics attenuated associations between AKI and all three outcomes, but AKI remained an independent risk factor. Attenuation of risk was similar after adjustment for absolute eGFR, eGFR slope, or proteinuria, individually or in combination. Conclusions Prehospitalization variables including eGFR, eGFR slope, and proteinuria confounded associations between AKI and adverse cardiovascular outcomes, but these associations remained significant after adjusting for prehospitalization variables.
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