m6A‐activated BACH1 exacerbates ferroptosis by epigenetic suppression HSPB1 in severe acute pancreatitis

氧化应激 炎症 细胞凋亡 热休克蛋白 急性胰腺炎 表观遗传学 发病机制 热冲击 癌症研究 细胞生物学 化学 生物 免疫学 医学 内分泌学 内科学 生物化学 基因
作者
Fawei Zhou,Dezhong Li,Chang Liu,Can Li,Kaili Li,Lu Shi,Fachun Zhou
出处
期刊:Drug Development Research [Wiley]
卷期号:85 (7)
标识
DOI:10.1002/ddr.22256
摘要

Abstract Severe acute pancreatitis (SAP) is characterized by acute inflammation of the pancreas. The transcription factor BTB and CNC homology 1 (BACH1) has been implicated in various biological processes, including oxidative stress, apoptosis, and cell cycle regulation. However, its involvement in the pathogenesis of SAP remains relatively understudied. In the present work, our data demonstrated that BACH1 level was significantly increased in SAP patients, cellular, and animal models, while heat shock protein B1 (HSPB1) expression was weakened. Mechanistic assays validated that BACH1 acted as a transcriptional inhibitor of HSPB1. Moreover, HPDE6‐C7 cells were stimulated with cerulein (Cer) and LPS to mimic the pathological stages of SAP in vitro. Depletion of BACH1 remarkably improved cell survival and alleviated the oxidative stress, ferroptosis, and inflammatory responses in SAP cell models. However, these changes were dramatically reversed upon co‐inhibition of HSPB1. Animal findings confirmed that loss of BACH1 decreased pancreatic injury, inflammatory responses, and ferroptosis, but these effects were weakened by HSPB1 silence. Overall, these findings elucidate that the overexpression of BACH1 favors the ferroptosis and inflammation by transcriptionally inhibiting HSBP1, thereby exacerbating SAP progression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
彭于晏应助Hua采纳,获得10
1秒前
dqh发布了新的文献求助10
1秒前
Andy发布了新的文献求助10
2秒前
2秒前
石橙星完成签到,获得积分10
2秒前
小毛发布了新的文献求助10
2秒前
曾经电源完成签到,获得积分10
4秒前
4秒前
MEMSforever发布了新的文献求助10
4秒前
wanci应助huhu采纳,获得10
4秒前
Cc发布了新的文献求助30
5秒前
16发布了新的文献求助10
5秒前
5秒前
xxx发布了新的文献求助10
6秒前
惠嘟嘟完成签到,获得积分10
6秒前
6秒前
丫丫完成签到,获得积分10
6秒前
gc完成签到,获得积分10
7秒前
二七完成签到 ,获得积分10
8秒前
ning发布了新的文献求助10
9秒前
dqh完成签到,获得积分10
10秒前
丫丫发布了新的文献求助10
10秒前
科目三应助pp采纳,获得10
11秒前
研六六发布了新的文献求助10
11秒前
12秒前
12秒前
李爱国应助柯米克采纳,获得10
12秒前
qy关注了科研通微信公众号
12秒前
冷艳的凡阳完成签到,获得积分10
12秒前
000完成签到,获得积分10
13秒前
14秒前
大模型应助阿月采纳,获得10
14秒前
14秒前
诚心的金毛完成签到,获得积分10
14秒前
15秒前
15秒前
脑洞疼应助如意元霜采纳,获得10
15秒前
傅宛白发布了新的文献求助20
15秒前
15秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546815
求助须知:如何正确求助?哪些是违规求助? 3123829
关于积分的说明 9357111
捐赠科研通 2822447
什么是DOI,文献DOI怎么找? 1551477
邀请新用户注册赠送积分活动 723475
科研通“疑难数据库(出版商)”最低求助积分说明 713766