Comparative effectiveness of pulsed field ablation and cryoballoon ablation for atrial fibrillation: a systematic review and meta-analysis

医学 烧蚀 心房颤动 荟萃分析 心脏病学 心脏消融 内科学 导管消融
作者
Marta V. Freitas,Larissa Araújo de Lucena,C Guida,Elísio Bulhões,Ricardo D’Oliveira Vieira,Isabelle Batista Donadon,Maria Esther Barbalho,Manuel Vilela,D Cazeiro,Dulce Brito,Joana Rodrigues Dantas
出处
期刊:European Heart Journal [Oxford University Press]
卷期号:45 (Supplement_1)
标识
DOI:10.1093/eurheartj/ehae666.376
摘要

Abstract Background Cryoballoon ablation (CBA) is a well-established technique for treating atrial fibrillation (AF), with a low complication rate related to cryoenergy-induced lesions. Pulsed Field Ablation (PFA) has emerged as a non-thermal alternative, with promising potential to further reduce complications. Purpose We aim to conduct a systematic review and meta-analysis comparing the efficacy and safety of PFA versus CBA in patients with AF. Methods We conducted a systematic search across PubMed, Embase, and the Cochrane Central Register of Controlled Trials to identify randomized controlled trials (RCTs) or observational studies published between 2013 and 2024 that compared PFA and CBA ablation techniques in patients with AF. Statistical analysis was carried out utilizing RevMan 5.1.7. Heterogeneity was assessed with I² statistics; p-values inferior to 0.05 and I²>25% were considered as significant heterogeneity. Results A total of 840 studies were screened in the initial search, and 26 studies were selected for full-text review based on inclusion criteria. Out of these, 8 observational studies involving 3,113 patients were included. Among these, 1,088 (34.9%) underwent PFA, while 2,025 (65.0%) underwent CBA. Periprocedural complications were significantly lower in patients who underwent PFA compared with the CBA group (RR 0.46; 95% CI 0.29 to 0.74; p=0.001; I²=1%; Fig. 1A). Furthermore, there was a significant reduction in procedure time in the PFA group (MD -8.21 min; 95% CI -13.74 to -2.69; p=0.004; I²=96%; Fig. 1B). However, no statistically significant difference was observed among groups regarding fluoroscopy time (MD 1.63 min; 95% CI -0.22 to 3.48; p=0.08; I²=92%; Fig. 2A), or recurrence of atrial arrhythmias after the blanking period (RR 0.84; 95% CI 0.68 to 1.04; p=0.12; I²=6%; Fig. 2B). Additionally, a subgroup analysis involving only propensity score-matched cohorts was conducted but didn’t show any statistical difference for any outcomes evaluated. Conclusion In this systematic review and meta-analysis, PFA was associated with a lower risk of periprocedural complications and a shorter procedure duration, compared to CBA in patients with AF. Additionally, it didn’t show a potential for reducing the recurrence of atrial arrhythmias, and the data regarding fluoroscopy time were inconclusive.Primary outcomesSecondary outcomes
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
华仔应助大橙子采纳,获得10
1秒前
小帅完成签到,获得积分10
1秒前
man完成签到 ,获得积分10
2秒前
biofresh完成签到,获得积分10
4秒前
平凡完成签到,获得积分10
8秒前
9秒前
哈利波特完成签到,获得积分10
12秒前
菓小柒完成签到 ,获得积分10
12秒前
basil完成签到,获得积分10
13秒前
大橙子发布了新的文献求助10
13秒前
mammer应助超帅无色采纳,获得10
14秒前
helloworld完成签到,获得积分10
15秒前
海洋完成签到,获得积分10
15秒前
Hina完成签到,获得积分10
16秒前
ZH完成签到,获得积分10
19秒前
yyds完成签到,获得积分10
20秒前
量子星尘发布了新的文献求助10
22秒前
23秒前
唯梦完成签到 ,获得积分10
23秒前
詹姆斯哈登完成签到,获得积分10
26秒前
李健应助名字不好起采纳,获得10
28秒前
万历完成签到,获得积分10
28秒前
28秒前
林卷卷完成签到,获得积分10
29秒前
大葱鸭发布了新的文献求助10
31秒前
32秒前
李健应助南山无梅落采纳,获得10
32秒前
36秒前
赘婿应助大橙子采纳,获得10
38秒前
45秒前
我是大学霸完成签到,获得积分10
46秒前
随风完成签到,获得积分0
46秒前
yi完成签到 ,获得积分10
47秒前
lin完成签到,获得积分10
48秒前
huahua完成签到 ,获得积分10
48秒前
大橙子发布了新的文献求助10
51秒前
小黑完成签到,获得积分10
54秒前
ZY完成签到 ,获得积分10
57秒前
阿士大夫完成签到,获得积分0
57秒前
chai完成签到,获得积分10
57秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022