Efficient Accessibility of Indole and Pyrrole Nuclei via Late-Stage Aryl C-H Activation of Drug Molecules Promoted by Thianthrenium Salts

An efficient redox-neutral palladium-catalyzed system has been developed to introduce indole and pyrrole to various bioactive molecules via late-stage aryl C–H activation, providing a robust tool to explore structure–activity relationships (SARs).