抑制因子
生长素
生物
拟南芥
同源染色体
基因
抄写(语言学)
转录调控
DNA结合蛋白
YY1年
转录因子
细胞生物学
遗传学
发起人
基因表达
突变体
哲学
语言学
作者
Hyung‐Taeg Cho,Minsu Lee,Hee-Seung Choi,Kwang-Ho Maeng,Kyeonghoon Lee,Ha-Yeon Lee,Anindya Ganguly,Hoonyoung Park,Chang-Hoi Ho
标识
DOI:10.1016/j.molp.2024.07.014
摘要
Combinatorial interactions between different regulators diversify and enrich the chance of transcriptional regulation in eukaryotic cells. However, a dose-dependent functional switch of homologous transcriptional repressors has rarely been reported. Here, we show that SHY2, an auxin/indole-3-acetic acid (Aux/IAA) repressor, exhibits a dose-dependent bimodal role in auxin-sensitive root-hair growth and gene transcription in Arabidopsis, whereas other Aux/IAA homologs consistently repress the auxin responses. The co-repressor (TOPLESS [TPL])-binding affinity of a bimodal Aux/IAA was lower than that of a consistently repressing Aux/IAA. The switch of a single amino acid residue in the TPL-binding motif between the bimodal form and the consistently repressing form switched their TPL-binding affinity and transcriptional and biological roles in auxin responses. Based on these data, we propose a model whereby competition between homologous repressors with different co-repressor-binding affinities could generate a bimodal output at the transcriptional and developmental levels.
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