A self-targeting MOFs nanoplatform for treating metastatic triple-negative breast cancer through tumor microenvironment remodeling and chemotherapy potentiation

三阴性乳腺癌 肿瘤微环境 癌症研究 转移 乳腺癌 转移性乳腺癌 化学 癌症 医学 内科学 肿瘤细胞
作者
Hao Chen,Ming Jin,Yanhong Liu,Shuangqing Wang,Chao Liu,Xiuquan Quan,Mingji Jin,Zhonggao Gao,Ying Jin
出处
期刊:International Journal of Pharmaceutics [Elsevier]
卷期号:664: 124625-124625 被引量:1
标识
DOI:10.1016/j.ijpharm.2024.124625
摘要

Triple-negative breast cancer (TNBC) is the most aggressive and fatal subtype of breast cancer with disappointing treatment and high mortality. Tumor microenvironment (TME) plays an important role in the invasion and metastasis of TNBC through multiple complex processes. Most anti-metastatic therapies only focus on cancer cells themselves or interfering with single factors of the metastasis process, which is often related to poor outcomes. Thus, effective TNBC treatment relies on regulating multiple key metastasis-related aspects of the TME. Herein, a self-targeting Metal-Organic Frameworks (MOFs) nanoplatform (named as MTX-PEG@TPL@ZIF-8) was designed to improve treatment of TNBC through tumor microenvironment remodeling and chemotherapy potentiation. The self-targeting MOF nanoplatform is consist of ZIF-8 nanoparticles loaded triptolide (TPL) and followed by the coating with methotrexate-polyethylene glycol conjugates (MTX-PEG). Due to MTX's affinity for the overexpressed folate receptor on tumor cell surfaces, MTX-PEG@TPL@ZIF-8 enables effective accumulation and deep penetration in the tumor area by an MTX-mediated self-targeting strategy. This MOF nanoplatform could promptly release the medication after penetrating the tumor cell, due to pH-triggered degradation. Its anti-metastasis mechanism is to inhibit tumor invasion and metastasis by down-regulating the expression of Vimentin, MMP-2 and MMP-9 and increasing the expression of E-cadherin, upregulation of cleaved caspase-3 and cleaved caspase-9 protein expression promote the apoptosis of tumor cells, thereby reducing their migration. It also downregulated the expression of VEGF and CD31 protein to inhibit the generation of neovascularization. Overall, these findings suggest the self-targeting MOF nanoplatform offers new insights into the treatment of metastatic TNBC by TME remodeling and potentiating chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
酷波er应助酷酷夏天采纳,获得10
刚刚
1秒前
hanwei_mei完成签到,获得积分10
5秒前
dkkjdsfakjd完成签到,获得积分10
6秒前
独特的紫蓝给娜娜的求助进行了留言
7秒前
7秒前
玉小赤给玉小赤的求助进行了留言
8秒前
SCH_zhu完成签到 ,获得积分10
8秒前
j7337完成签到,获得积分10
10秒前
10秒前
11秒前
尔信完成签到 ,获得积分10
11秒前
14秒前
Hello应助能HJY采纳,获得10
15秒前
15秒前
斯文败类应助一手少年采纳,获得10
15秒前
852应助艾米采纳,获得10
16秒前
小邹发布了新的文献求助10
16秒前
香蕉觅云应助愤怒的树叶采纳,获得10
17秒前
杜康完成签到,获得积分10
18秒前
年轻水壶完成签到 ,获得积分10
19秒前
19秒前
19秒前
情怀应助carryxu采纳,获得10
20秒前
shizhf999发布了新的文献求助10
20秒前
20秒前
欣慰问凝发布了新的文献求助10
20秒前
21秒前
LD完成签到 ,获得积分10
21秒前
聪明的金针菇完成签到,获得积分20
23秒前
24秒前
24秒前
一指墨发布了新的文献求助10
24秒前
26秒前
南枝瑾发布了新的文献求助10
26秒前
unique发布了新的文献求助10
27秒前
小小莫发布了新的文献求助10
28秒前
杨嘟嘟完成签到,获得积分10
28秒前
28秒前
112234发布了新的文献求助10
28秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256267
求助须知:如何正确求助?哪些是违规求助? 2898511
关于积分的说明 8301297
捐赠科研通 2567706
什么是DOI,文献DOI怎么找? 1394629
科研通“疑难数据库(出版商)”最低求助积分说明 652895
邀请新用户注册赠送积分活动 630548