医学
放射性核素治疗
转移
垂体瘤
神经内分泌肿瘤
生长抑素受体
正电子发射断层摄影术
催乳素
癌
内科学
病理
生长抑素
癌症研究
肿瘤科
核医学
癌症
激素
作者
Nitish Agarwal,Satish Verma,Vikram Raj Gopinathan,Seema Kaushal,Anima Sharma,Sarat P. Chandra
出处
期刊:Neurology India
[Medknow Publications]
日期:2024-07-01
卷期号:72 (4): 871-876
标识
DOI:10.4103/neurol-india.neurol-india-d-24-00529
摘要
Pituitary carcinoma is a rare entity comprising 0.1–0.2% of all pituitary tumors and presents significant diagnostic and therapeutic challenges. Intraspinal drop metastasis in these tumors is even rarer. We report a case of a prolactin secreting pituitary carcinoma with intracranial metastasis and multiple intraspinal drop metastasis. This is the first case where 68 Gallium labelled [1,4,7,10 – tetraazacyclododecane – 1,4,7,10 – tetraacetic acid] -1- NaI 3 - octreotide ( 68 Ga-DOTANOC) whole-body positron emission tomography–computed tomography (PET-CT) has been used in a case of malignant prolactinoma, in an attempt to ascertain the somatostatin receptor (SSTR) expression on tumor cells. Through this paper, we suggest that SSTR targeted radionuclide therapy could have a potential role in aggressive pituitary tumors and pituitary carcinomas similar to the promising role of lutetium-labelled peptides in inoperable or metastasized gastroentero-pancreatic neuroendocrine tumors (GEP-NETs).
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