药物输送
药品
活性成分
生物利用度
溶解度
并行传输
药理学
药学
剂型
化学
纳米技术
生化工程
磁导率
医学
材料科学
有机化学
工程类
膜
生物化学
作者
Omar Khan,Rohit Bhawale,Ravindra Vasave,Neelesh Kumar Mehra
标识
DOI:10.1016/j.drudis.2024.104109
摘要
The utilization of ionic liquids (ILs) in pharmaceutical drug delivery applications has seen significant expansion in recent years, owing to their distinctive characteristics and inherent adjustability. These innovative compounds can be used to tackle challenges associated with traditional dosage forms, such as polymorphism, inadequate solubility, permeability, and efficacy in topical drug delivery systems. Here, we provide a brief classification of ILs, and their effectiveness in augmenting transmucosal drug delivery approaches by improving the solubility and permeability of active pharmaceutical ingredients (APIs) by temporary mucus modulation aiding the paracellular transport of APIs, prolonging drug retention, and, thus, aiding controlled drug release across various mucosal surfaces. We also highlight potential advances in, and future perspectives of, IL-based formulations in mucosal drug delivery.
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