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Racial variability in immune responses only partially explains differential systemic sclerosis disease severity

医学 疾病 免疫系统 免疫学 硬皮病(真菌) 多发性硬化 全身性疾病 免疫病理学 内科学 接种
作者
Kamini Kuchinad,Ji Soo Kim,Adrianne Woods,Gwen Leatherman,Laura Gutierrez‐Alamillo,Maureen D. Mayes,Robyn T. Domsic,Paula S. Ramos,Richard M. Silver,John Varga,Lesley Ann Saketkoo,Suzanne Kafaja,Victoria K Shanmugan,Jessica Gordon,Leland W.K. Chung,Elana J. Bernstein,Pravitt Gourh,Francesco Boin,Daniel L. Kastner,Scott L. Zeger
出处
期刊:Annals of the Rheumatic Diseases [BMJ]
卷期号:: ard-225458
标识
DOI:10.1136/ard-2023-225458
摘要

Objective To understand if autoantibodies account for racial variation in disease severity, we compared autoantibody distribution and associated phenotype between self-identified black and white systemic sclerosis (SSc) patients. Methods 803 black and 2178 white SSc patients had systematic testing for autoantibodies using Euroimmun (centromere (ACA), RNA-polymerase III (POLR3), Scl70, PM/Scl, NOR90, Th/To, Ku, U3RNP and Ro52) and commercial ELISA (U1RNP). In this observational study, logistic regression was performed to assess the association between self-identified race and outcomes, adjusting for autoantibodies. To estimate whether the effect of race was mediated by autoantibody status, race coefficients from multivariate models including and excluding autoantibodies were compared. Results Anti-Scl70, anti-U1RNP, anti-U3RNP, anti-Th/To, anti-Ku and anti-NOR90 were more common in the black cohort than in the white cohort, which was enriched for ACA, anti-POLR3 and anti-PM/Scl. Black individuals had a higher prevalence of severe Raynaud’s, skin, lung, gastrointestinal and renal disease whereas white individuals had a higher prevalence of severe heart and muscle disease. Adjusting for autoantibodies decreased the effect of race on outcome for telangiectasias, forced vital capacity <70%, pulmonary hypertension and severe lung, heart, muscle and gastrointestinal disease by 11%–44% and increased the association between race and renal crisis and severe kidney disease by 37%–52%. Conclusions This study is the largest systematic analysis of autoantibody responses in a geographically diverse population of black SSc patients. Black and white individuals with SSc have distinct autoantibody profiles. Autoantibodies explain only a fraction of the effect of race on clinical outcomes, suggesting other factors contribute to disparate outcomes between these groups.
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