医学
乳腺癌
内科学
荟萃分析
尿酸
肿瘤科
癌症
入射(几何)
风险因素
妇科
物理
光学
作者
Xin Xue,NULL AUTHOR_ID,NULL AUTHOR_ID,Hua Lin,NULL AUTHOR_ID,NULL AUTHOR_ID
标识
DOI:10.1016/j.amjms.2024.07.005
摘要
BackgroundSerum uric acid (SUA) may be involved in the development of cancer by inhibiting oxidative stress, but its relationship with breast cancer remains unclear.MethodsThe PubMed, Embase, and Web of Science databases were searched systematically for studies on SUA levels in women with breast cancer and the effect of SUA levels on the risk of breast cancer. The Newcastle‒Ottawa Quality Assessment Scale (NOS) was used to assess the quality of all relevant studies included.ResultsA total of 19 studies were included, including 75,827 women with breast cancer and 508,528 healthy controls. A meta-analysis found that SUA levels were negatively correlated with breast cancer risk in women (HR = 0.94, 95% CI: 0.89 - 0.99, p = 0.003). SUA levels in female breast cancer patients were not significantly different from those in healthy controls (SMD = 0.49, 95% CI = -0.09 - 1.08, p = 0.10), while SUA levels were increased in female breast cancer patients in articles published after 2010, SUA concentration detected by spectrophotometry, and non-Asian populations, regardless of menopausal state and treatment state.ConclusionHigh levels of SUA may reduce the risk of breast cancer in women, suggesting that SUA was a protective factor in women.
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