Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients

高强度 白质 认知 体素 病变 记忆诊所 医学 听力学 心脏病学 心理学 认知障碍 神经科学 放射科 精神科 磁共振成像
作者
Mirthe Coenen,Hugo J. Kuijf,Irene M.C. Huenges Wajer,Marco Duering,Frank J. Wolters,Evan F. Fletcher,Pauline Maillard,Frederik Barkhof,Josephine Barnes,Thomas Benke,Jooske M.F. Boomsma,Christopher Chen,Peter Dal‐Bianco,Anna Dewenter,Christian Enzinger,Michael Ewers,Lieza G. Exalto,Nicolai Franzmeier,Onno N. Groeneveld,Saima Hilal,Edith Hofer,Dineke L. Koek,Andrea B. Maier,Cheryl R. McCreary,Catarina S. Padilla,Janne M. Papma,Ross W. Paterson,Yolande A.L. Pijnenburg,Anna Rubinski,Reinhold Schmidt,Jonathan M. Schott,Catherine F. Slattery,Eric E. Smith,Rebecca M. E. Steketee,Carole H. Sudre,Esther van den Berg,Wiesje M. van der Flier,Narayanaswamy Venketasubramanian,Meike W. Vernooij,Xin Xu,Charles DeCarli,Geert Jan Biessels,J. Matthijs Biesbroek
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:19 (6): 2420-2432 被引量:34
标识
DOI:10.1002/alz.12827
摘要

Abstract Introduction Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Methods Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel‐based and region of interest tract‐based analyses. Results WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto‐occipital fasciculus were significantly related to domain‐specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. Discussion The data show that the impact of WMH on cognition is location‐dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. Highlights We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains
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