生命银行
类有机物
医学
人口
球体
腺癌
细胞
结直肠癌
肿瘤科
药物发现
癌症研究
内科学
癌症
生物信息学
生物
细胞培养
神经科学
遗传学
环境卫生
作者
Igor Tokarchuk,Oleksandr Mushii,Alona Dreus,Anastasia A. Koziaruk,Dmytro Shapochka,Oleg A. Ryzhak,Serhii O. Venhryk,Iurii S. Golovko,Sergey V. Ryabuhin,Anton I. Hanopolskyi,Duncan B. Judd,Dmitriy M. Volochnyuk
标识
DOI:10.1101/2023.02.26.529716
摘要
Abstract Gastric and colorectal cancer models are essential for the advancement of precision medicine discovery and development. 2D attached monolayer, spheroid and organoid approaches have all been used in the formation of biobanks containing primary patient-derived cells. Here, we report an assessment of those procedures for a panel of nine patient-derived adenocarcinoma samples, along with the most applicable method for the bio-banking of these cell types. A live cell biobank of tumour specimens would facilitate drug discovery laboratories to evaluate drugs on the population of cell cultures, prior to the clinical phase.
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