Vibrational coupling with O–H stretching increases catalytic efficiency of sucrase in Fabry–Pérot microcavity

Vibrational strong coupling (VSC) has been reported as a polariton-based method for modulating the rate of biochemical reactions. Herein, we studied how VSC modulates the sucrose hydrolysis. By monitoring the refractive index-induced shift of Fabry–Pérot microcavity, in which the catalytic efficiency of sucrose hydrolysis can be increased at least two times, as VSC was tuned to resonate with the stretching vibration of O–H bonds. This research provides new evidence for applying VSC in life sciences, which holds great promise to improving enzymatic industries.