脱氧核酶
适体
癌细胞
细胞内
化学
细胞生物学
线粒体
劈理(地质)
肿瘤微环境
癌症
细胞凋亡
纳米技术
癌症研究
生物化学
生物
肿瘤细胞
分子生物学
DNA
材料科学
遗传学
古生物学
断裂(地质)
作者
Ruo‐Can Qian,Ze‐Rui Zhou,Yuting Wu,Zhenglin Yang,Weijie Guo,Dawei Li,Yi Lu
标识
DOI:10.1002/anie.202210935
摘要
Despite the promise of combination cancer therapy, it remains challenging to develop targeted strategies that are nontoxic to normal cells. Here we report a combination therapeutic strategy based on engineered DNAzyme molecular machines that can promote cancer apoptosis via dynamic inter- and intracellular regulation. To achieve external regulation of T-cell/cancer cell interactions, we designed a DNAzyme-based molecular machine with an aptamer and an i-motif, as the MUC-1-selective aptamer allows the specific recognition of cancer cells. The i-motif is folded under the tumor acidic microenvironment, shortening the intercellular distance. As a result, T-cells are released by metal ion activated DNAzyme cleavage. To achieve internal regulation of mitochondria, we delivered another DNAzyme-based molecular machine with mitochondria-targeted peptides into cancer cells to induce mitochondria aggregation. Our strategy achieved an enhanced killing effect in zinc deficient cancer cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI