酿酒酵母
血红素
生物合成
化学
生物化学
酵母菌
酵母
酶
作者
Fan Liu,Xiaoyan Sun,Jingwen Zhou,Jianghua Li,Jian Chen,Guocheng Du,Xinrui Zhao
出处
期刊:FEBS Journal
[Wiley]
日期:2024-06-12
卷期号:291 (16): 3737-3748
摘要
Hemoglobins, with heme as a cofactor, are functional proteins that have extensive applications in the fields of artificial oxygen carriers and foods. Although Saccharomyces cerevisiae is an ideal host for hemoglobin synthesis, it lacks a suitable transport system to utilize additional heme for active expression of hemoglobins, resulting in the cellular aggregation and degradation of the latter. Here, an effective heme importer, heme-responsive gene 4 (Hrg-4), was selected from six candidates through the comparison of effects on the growth rates of Δhem1 S. cerevisiae strain and the activities of various hemoglobins when supplemented with 5 mg·L
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