生物
鉴定(生物学)
分子生物标志物
计算生物学
内科学
癌症研究
医学
植物
作者
Mingyue Li,Yahui Liu,Wei Feng,Ping Zhang,Xiaodong Sun,Meng Wang,Xiaohong Du,Jun-Feng Ye,Wei Qiu,Xiaoju Shi,Bai Ji,Yingchao Wang,Chao Jiang,Wengang Chai,Bo Huang,Xing-Kai Liu,Qing-Min Chen,Yu Fu,Xintong Hu,Liguo Chen
出处
期刊:Genomics
[Elsevier BV]
日期:2024-06-18
卷期号:116 (5): 110889-110889
标识
DOI:10.1016/j.ygeno.2024.110889
摘要
Cholangiocarcinoma (CCA) is widely noted for its high degree of malignancy, rapid progression, and limited therapeutic options. This study was carried out on transcriptome data of 417 CCA samples from different anatomical locations. The effects of lipid metabolism related genes and immune related genes as CCA classifiers were compared. Key genes were derived from MVI subtypes and better molecular subtypes. Pathways such as epithelial mesenchymal transition (EMT) and cell cycle were significantly activated in MVI-positive group. CCA patients were classified into three (four) subtypes based on lipid metabolism (immune) related genes, with better prognosis observed in lipid metabolism-C1, immune-C2, and immune-C4. IPTW analysis found that the prognosis of lipid metabolism-C1 was significantly better than that of lipid metabolism-C2 + C3 before and after correction. KRT16 was finally selected as the key gene. And knockdown of KRT16 inhibited proliferation, migration and invasion of CCA cells.
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