组织工程
生物材料
心肌梗塞
心力衰竭
重症监护医学
再生(生物学)
再生医学
医学
生物相容性材料
干细胞
风险分析(工程)
生物医学工程
心脏病学
生物
遗传学
细胞生物学
作者
Zahra-Sadat Razavi,M. Soltani,Golnaz Mahmoudvand,Simin Farokhi,Arian Karimi-Rouzbahani,Bahareh Farasati-Far,Samaneh Tahmasebi-Ghorabi,Hamidreza Pazoki‐Toroudi,Hamed Afkhami
标识
DOI:10.3389/fbioe.2024.1385124
摘要
Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of a large number of cardiomyocytes (CMs), which the adult heart struggles to replenish due to its limited regenerative capacity. Consequently, this deficit in CMs often precipitates severe complications such as heart failure (HF), with whole heart transplantation remaining the sole definitive treatment option, albeit constrained by inherent limitations. In response to these challenges, the integration of bio-functional materials within cardiac tissue engineering has emerged as a groundbreaking approach with significant potential for cardiac tissue replacement. Bioengineering strategies entail fortifying or substituting biological tissues through the orchestrated interplay of cells, engineering methodologies, and innovative materials. Biomaterial scaffolds, crucial in this paradigm, provide the essential microenvironment conducive to the assembly of functional cardiac tissue by encapsulating contracting cells. Indeed, the field of cardiac tissue engineering has witnessed remarkable strides, largely owing to the application of biomaterial scaffolds. However, inherent complexities persist, necessitating further exploration and innovation. This review delves into the pivotal role of biomaterial scaffolds in cardiac tissue engineering, shedding light on their utilization, challenges encountered, and promising avenues for future advancement. By critically examining the current landscape, we aim to catalyze progress toward more effective solutions for cardiac tissue regeneration and ultimately, improved outcomes for patients grappling with cardiovascular ailments.
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