氧化应激
NAD+激酶
凝集素
衰老
甘露聚糖结合凝集素
氧化磷酸化
化学
生物化学
甘露聚糖
细胞生物学
生物
酶
多糖
作者
Yongquan Lei,Haiqiang Shi,Haiqiang Shi,Haiqiang Shi,Haiqiang Shi,Haiqiang Shi,Daming Zuo,Daming Zuo,Daming Zuo,Mingyong Wang
标识
DOI:10.1016/j.intimp.2024.112468
摘要
Prolonged or excessive oxidative stress can lead to premature cellular and body aging. Mannan-binding lectin (MBL) is synthesized by the liver and plays an important role in innate immunity, anti-inflammation, and anti-oxidation, and has a positive impact on health and longevity. To date, few studies investigated the role of MBL in attenuating oxidative stress-induced senescence. In this study, we evaluated the role of MBL in oxidative stress-induced premature aging and explored its underlying mechanism in C57BL/6 mice and mouse embryonic fibroblasts (NIH/3T3). First, we established an oxidative premature senescence model induced by D-galactose in C57BL/6 mice. We found that MBL-deficient mice had a marked aging-like appearance, reduced learning and spatial exploration abilities, severe liver pathological damage, and significantly upregulated expression of Senescence-associated proteins (p53 and p21), inflammatory kinesins (IL-1β and IL-6), and the senescence β-galactosidase (SA-β-Gal) positive rate as compared with WT mice. In the H
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