血管生成
材料科学
血管内皮生长因子
生物物理学
机械敏感通道
细胞生物学
纳米技术
生物医学工程
受体
化学
癌症研究
生物化学
生物
离子通道
医学
血管内皮生长因子受体
作者
Zhuochang Cai,Cheng Qu,Wei Song,Haoyuan Wang,Shuai Chen,Chao Zhou,Cunyi Fan
标识
DOI:10.1002/adma.202404842
摘要
Revascularization after rotator cuff repair is crucial for tendon-to-bone healing. The chirality of materials has been reported to influence their performance in tissue repair. However, data on the use of chiral structures to optimize biomaterials as a revascularization strategy remain scarce. Here, calcium silicate hydrate (CSO) films with hierarchical chirality on the atomic to micrometer scale are developed. Interestingly, levorotatory CSO (L-CSO) films promote the migration and angiogenesis of endothelial cells, whereas dextral and racemic CSO films do not induce the same effects. Molecular analysis demonstrates that L-chirality can be recognized by integrin receptors and leads to the formation of focal adhesion, which activates mechanosensitive ion channel transient receptor potential vanilloid 4 to conduct Ca
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