银屑病
炎症
基质金属蛋白酶
金属蛋白酶
医学
免疫学
癌症研究
内科学
作者
Canbin Dong,Jui-Ming Lin,Xiaonian Lu,Junhao Zhu,Lanmei Lin,Jinhua Xu,Juan Du
摘要
Psoriasis, a T cell-mediated chronic inflammatory skin condition, is characterized by the interaction of T cells with various cell types, forming an inflammatory microenvironment that sustains psoriatic inflammation. The homeostasis of these tissue-resident T cells are supported by fibroblasts, the primary structural cells in the dermis. In psoriasis, there is an increased expression of matrix metalloproteinase 2 (MMP2), mediating the structural alterations of skin tissues and the modulation of inflammation. Additionally, the CD100-PLXNB2 axis is known to enhance psoriasis inflammation via keratinocytes, and CD103 levels are associated with the severity of psoriasis upon relapse.
科研通智能强力驱动
Strongly Powered by AbleSci AI