Harnessing Graphdiyne for Selective Cu2+ Detection: A Promising Tool for Parkinson’s Disease Diagnostics and Pathogenesis

吸附 发病机制 电化学 金属 密度泛函理论 离子 石墨烯 水溶液中的金属离子 材料科学 选择性 碳纤维 化学 纳米技术 物理化学 计算化学 电极 生物化学 有机化学 生物 催化作用 复合材料 复合数 免疫学
作者
Jing Jiang,Xu Wang,Yongqi Bao,Fangxu Shen,Guo Wang,Kai Li,Yuqing Lin
出处
期刊:ACS Sensors [American Chemical Society]
卷期号:9 (5): 2317-2324
标识
DOI:10.1021/acssensors.4c00633
摘要

Cu2+ accelerates the viral-like propagation of α-synuclein fibrils and plays a key role in the pathogenesis of Parkinson's disease (PD). Therefore, the accurate detection of Cu2+ is essential for the diagnosis of PD and other neurological diseases. The Cu2+ detection process is impeded by substances that have similar electrochemical properties. In this study, graphdiyne (GDY), a new kind of carbon allotrope with strong electron-donating ability, was utilized for the highly selective detection of Cu2+ by taking advantage of its outstanding adsorption capacity for Cu2+. Density functional theory (DFT) calculations show that Cu atoms are adsorbed in the cavity of GDY, and the absorption energy between Cu and C atoms is higher than that of graphene (GR), indicating that the cavity of GDY is favorable for the adsorption of Cu atoms and electrochemical sensing. The GDY-based electrochemical sensor can effectively avoid the interference of amino acids, metal ions and neurotransmitters and has a high sensitivity of 9.77 μA·μM–1·cm–2, with a minimum detectable concentration of 200 nM. During the investigating pathogenesis and therapeutic process of PD with α-synuclein as the diagnostic standard, the concentration of Cu2+ in cells before and after L-DOPA and GSH treatments were examined, and it was found that Cu2+ exhibits high potential as a biomarker for PD. This study not only harnesses the favorable adsorption of the GDY and Cu2+ to improve the specificity of ion detection but also provide clues for deeper understanding of the role of Cu2+ in neurobiology and neurological diseases.
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