Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study

听力学 执行障碍综合征 肌萎缩侧索硬化 神经心理学 认知 考试(生物学) 心理学 波士顿命名测验 接收机工作特性 试制试验 执行功能障碍 失智症 痴呆 执行职能 神经心理学测验 神经心理评估 语言学习 认知测验 医学 精神科 疾病 内科学 古生物学 生物
作者
Reiko Ohdake,Hirohisa Watanabe,Kazuya Kawabata,Aya Ogura,Maki Sato,Yasuhiro Tanaka,Kazunori Imai,Michihito Masuda,Toshiyasu Kato,Takamasa Yokoi,Kazuhiro Hara,Ryoichi Nakamura,Naoki Atsuta,Masafumi Nakagawa,Masahisa Katsuno,Gen Sobue
出处
期刊:Archives of Clinical Neuropsychology [Oxford University Press]
卷期号:38 (1): 57-71 被引量:1
标识
DOI:10.1093/arclin/acac069
摘要

Abstract Objective About 30%–50% of patients with amyotrophic lateral sclerosis (ALS) show cognitive impairment ranging from mild dysexecutive syndrome to frontotemporal dementia. We aimed to develop a brief cognitive test, convenient auditory-based language and executive function test (CABLET), for rapid detection of cognitive impairment in ALS, with reduced load on motor function. Method The CABLET comprises two tests using auditory verbal stimuli: Test 1, assessing word repetition and lexical judgment, and Test 2, evaluating verbal short-term memory and semantics knowledge. The administration time of Test 1 and Test 2 was 1 and 3–5 min, respectively. Overall, 61 patients with ALS and 46 age-, sex-, and education-matched healthy controls participated in this study. All participants underwent existing neuropsychological tests and the CABLET. We investigated the applicability of the CABLET to detect ALS with cognitive impairment (ALSci) from normal cognition. Results Receiver operating characteristic analyses showed that both the CABLET total and Test 2 had good diagnostic accuracy (area under the curve [AUC]: total = 0.894, Test 2 = 0.893). Test 2 had the highest sensitivity (100% sensitivity and 71.4% specificity). No significant difference existed in the AUC between the analyses with and without age, education, and disease severity as covariates. Correlations were observed between the CABLET and established neuropsychological tests, supporting its good convergent validity. Conclusions Our findings indicated that the CABLET could be useful in identifying ALSci quickly without adjusting for confounding factors. Further validation is required to evaluate it in larger groups and compare with ALS-specific cognitive screen.

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