多发性骨髓瘤
抗体
双特异性抗体
细胞
抗体反应
免疫学
癌症研究
医学
生物
单克隆抗体
遗传学
作者
Christie P.M. Verkleij,Chloe O’Neill,Marloes E.C. Broekmans,Kristine A. Frerichs,Wassilis S.C. Bruins,Carolien Duetz,Sandy Kruyswijk,S. Rubina Baglio,Sheri Skerget,Rocío Montes de,Sonja Zweegman,Raluca Verona,Tuna Mutis,Niels W.C.J. van de Donk
标识
DOI：10.1158/1078-0432.ccr-23-3333
摘要
Primary resistance is characterized by a low T-cell/multiple myeloma cell ratio and Treg-driven immunosuppression, whereas reduced T-cell fitness due to continuous BsAb-mediated T-cell activation may contribute to the development of acquired resistance.
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(2025-6-4)
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