Incorporating plan complexity into the statistical process control of volumetric modulated arc therapy pre‐treatment verifications

统计过程控制 计算机科学 控制图 质量保证 平面图(考古学) 过程(计算) 控制限值 启发式 差异(会计) 偏斜 数据挖掘 人工智能 统计 数学 运营管理 工程类 考古 操作系统 外部质量评估 会计 业务 历史
作者
S. Russo,Jordi Sáez,M. Esposito,A. Bruschi,A. Ghirelli,S. Pini,S. Scoccianti,Víctor Hernández
出处
期刊:Medical Physics [Wiley]
卷期号:51 (6): 3961-3971 被引量:2
标识
DOI:10.1002/mp.17081
摘要

Abstract Background Statistical process control (SPC) is a powerful statistical tool for process monitoring that has been highly recommended in healthcare applications, including radiation therapy quality assurance (QA). The AAPM TG‐218 report described the clinical implementation of SPC for Volumetric Modulated Arc Therapy (VMAT) pre‐treatment verifications, pointing out the need to adjust tolerance limits based on plan complexity. However, the quantification of plan complexity and its integration into SPC remains an unresolved challenge. Purpose The primary aim of this study is to investigate the incorporation of plan complexity into the SPC framework for VMAT pre‐treatment verifications. The study explores and evaluates various strategies for this incorporation, discussing their merits and limitations, and provides recommendations for clinical application. Methods A retrospective analysis was conducted on 309 VMAT plans from diverse anatomical sites using the PTW OCTAVIUS 4D device for QA measurements. Gamma Passing Rates (GPR) were obtained, and lower control limits were computed using both the conventional Shewhart method and three heuristic methods (scaled weighted variance, weighted standard deviations, and skewness correction) to accommodate non‐normal data distributions. The ‘Identify‐Eliminate‐Recalculate’ method was employed for robust analysis. Eight complexity metrics were analyzed and two distinct strategies for incorporating plan complexity into SPC were assessed. The first strategy focused on establishing control limits for different treatment sites, while the second was based on the determination of control limits as a function of individual plan complexity. The study extensively examines the correlation between control limits and plan complexity and assesses the impact of complexity metrics on the control process. Results The control limits established using SPC were strongly influenced by the complexity of treatment plans. In the first strategy, a clear correlation was found between control limits and average plan complexity for each site. The second approach derived control limits based on individual plan complexity metrics, enabling tailored tolerance limits. In both strategies, tolerance limits inversely correlated with plan complexity, resulting in all highly complex plans being classified as in control. In contrast, when plans were collectively analyzed without considering complexity, all the out‐of‐control plans were highly complex. Conclusions Incorporating plan complexity into SPC for VMAT verifications requires meticulous and comprehensive analysis. To ensure overall process control, we advocate for stringent control and minimization of plan complexity during treatment planning, especially when control limits are adjusted based on plan complexity.
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