Microvascular disease, modifiable risk factor profiles and incident arrhythmias in type 2 diabetes

医学 风险因素 2型糖尿病 内科学 疾病 糖尿病 心脏病学 体质指数 肾脏疾病 危险系数 内分泌学 置信区间
作者
Guo‐Chong Chen,Daniel Nyarko Hukportie,Wei-Dong Fan,Jie-Qiong Lyu,Haipeng Wang,Li‐Qiang Qin,Xianbo Wu,Fu‐Rong Li
出处
期刊:Heart [BMJ]
卷期号:110 (11): 776-782 被引量:1
标识
DOI:10.1136/heartjnl-2023-323527
摘要

Background To assess the roles of diabetic microvascular disease and modifiable risk factors and their combination in the development of arrhythmias. Methods We included participants with type 2 diabetes (T2D) who were free of arrhythmias during recruitment in the UK Biobank study. The associations of microvascular disease states (defined by the presence of retinopathy, peripheral neuropathy or chronic kidney disease), four modifiable arrhythmic risk factors (body mass index, smoking, systolic blood pressure and glycosylated haemoglobin) and their joint associations with incident arrhythmias were examined. Results Among the 25 632 participants with T2D, 1705 (20.1%) of the 8482 with microvascular disease and 2017 (11.8%) of the 17 150 without microvascular disease developed arrhythmias during a median follow-up of 12.3 years. Having any of the three microvascular diseases was associated with a 48% increase in the hazard of developing arrhythmias. Incorporating microvascular disease states into a model alongside 11 traditional risk factors significantly enhanced arrhythmia prediction. Furthermore, individuals with microvascular disease who had optimal levels of zero to one, two, three or four arrhythmic risk factors showed an HR of 2.05 (95% CI 1.85, 2.27), 1.67 (95% CI 1.53, 1.83), 1.35 (95% CI 1.22, 1.50) and 0.91 (95% CI 0.73, 1.13), respectively, compared with those without microvascular disease. Conclusions Although microvascular disease, a non-traditional risk factor, was associated with incident arrhythmias in individuals with T2D, having optimal levels of risk factors may mitigate this risk.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
珞珈完成签到,获得积分10
刚刚
Ya完成签到,获得积分10
刚刚
谦让文昊完成签到,获得积分10
1秒前
小红勇闯科研界完成签到,获得积分10
3秒前
科研通AI2S应助长安采纳,获得10
5秒前
5秒前
6秒前
Amber完成签到,获得积分10
6秒前
6秒前
teborlee完成签到,获得积分10
7秒前
xinxin完成签到,获得积分10
7秒前
SYLH应助鳗鱼鸽子采纳,获得10
7秒前
YY完成签到,获得积分10
8秒前
老德完成签到,获得积分10
8秒前
靓丽的熠彤完成签到,获得积分10
9秒前
深情海秋完成签到,获得积分10
9秒前
10秒前
歇洛克完成签到,获得积分10
11秒前
cao完成签到,获得积分20
11秒前
为你博弈完成签到,获得积分10
12秒前
12秒前
于情信芳完成签到,获得积分10
12秒前
庚小马发布了新的文献求助10
12秒前
淡然妙竹发布了新的文献求助10
13秒前
炒栗子发布了新的文献求助10
13秒前
晴云发布了新的文献求助10
13秒前
14秒前
PHW完成签到,获得积分10
14秒前
monly应助Fin2046采纳,获得30
15秒前
Hello应助JJG采纳,获得10
15秒前
李健的小迷弟应助WJH采纳,获得10
15秒前
17秒前
ty发布了新的文献求助10
17秒前
刘逸藩完成签到,获得积分10
17秒前
yulian完成签到,获得积分10
18秒前
chemhub完成签到,获得积分10
18秒前
歇洛克发布了新的文献求助10
18秒前
Lee发布了新的文献求助10
18秒前
18秒前
慢慢发布了新的文献求助10
19秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048