Clinical Assessment of Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging in Diffuse Glioma: Insights Into Histological Grading and IDH Classification

医学 分级(工程) 胶质瘤 曼惠特尼U检验 接收机工作特性 磁共振弥散成像 磁共振成像 异柠檬酸脱氢酶 肿瘤分级 有效扩散系数 核医学 病理 放射科 内科学 免疫组织化学 核磁共振 土木工程 物理 癌症研究 工程类
作者
Hanwen Zhang,Hongbo Zhang,Xiaolei Liu,Hua-Zhen Deng,Yuzhe Zhang,Xu-Mei Tang,Fan Lin,Biao Huang
出处
期刊:Canadian Association of Radiologists journal [SAGE Publishing]
被引量:1
标识
DOI:10.1177/08465371241238917
摘要

Purpose: To assess the diagnostic utility of clinical magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in distinguishing between histological grading and isocitrate dehydrogenase ( IDH) classification in adult diffuse gliomas. Methods: A retrospective analysis was conducted on 247 patients diagnosed with adult diffuse glioma. Experienced radiologists evaluated DWI and MRS images. The Kruskal-Wallis test examined differences in DWI and MRS-related parameters across histological grades, while the Mann–Whitney U test assessed molecular classification. Receiver Operating Characteristic (ROC) curves evaluated parameter effectiveness. Survival curves, stratified by histological grade and IDH classification, were constructed using the Kaplan–Meier test. Results: The cohort comprised 141 males and 106 females, with ages ranging from 19 to 85 years. The Kruskal-Wallis test revealed significant differences in ADC mean, Cho/NAA, and Cho/Cr concerning glioma histological grade ( P < .01). Subsequent application of Dunn’s test showed significant differences in ADC mean among each histological grade ( P < .01). Notably, Cho/NAA exhibited a marked distinction between grade 2 and grade 3/4 gliomas ( P < .01). The Mann–Whitney U test indicated that only ADC mean showed statistical significance for IDH molecular classification ( P < .01). ROC curves were constructed to demonstrate the effectiveness of the specified parameters. Survival curves were also delineated to portray survival outcomes categorized by histological grade and IDH classification. Conclusions: Clinical MRS demonstrates efficacy in glioma histological grading but faces challenges in IDH classification. Clinical DWI’s ADC mean parameter shows significant distinctions in both histological grade and IDH classification.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
缥缈忻完成签到,获得积分10
刚刚
1秒前
ASH发布了新的文献求助10
4秒前
852应助如意代秋采纳,获得10
5秒前
祝愿发布了新的文献求助10
5秒前
8秒前
8秒前
daoyi完成签到,获得积分10
9秒前
9秒前
10秒前
13秒前
flow完成签到,获得积分10
14秒前
123gg发布了新的文献求助10
14秒前
zong2807完成签到,获得积分10
15秒前
阿菜完成签到,获得积分10
15秒前
泥嚎发布了新的文献求助10
16秒前
18秒前
tuanheqi应助研友_LXjjOZ采纳,获得150
18秒前
酷波er应助北北采纳,获得10
21秒前
田様应助CHRIS采纳,获得10
21秒前
小焦儿完成签到,获得积分10
22秒前
万能图书馆应助坚定白风采纳,获得10
22秒前
丘比特应助小任性采纳,获得10
22秒前
所所应助liziqi采纳,获得10
23秒前
雪白的夏山完成签到,获得积分10
30秒前
失眠的广山完成签到 ,获得积分10
30秒前
35秒前
36秒前
星辰大海应助大喵采纳,获得10
38秒前
39秒前
40秒前
40秒前
keyantong发布了新的文献求助10
40秒前
薛妖怪发布了新的文献求助10
40秒前
小任性发布了新的文献求助10
41秒前
南瓜饼完成签到,获得积分10
42秒前
漂亮白枫发布了新的文献求助10
43秒前
zhxq发布了新的文献求助10
44秒前
44秒前
rhei发布了新的文献求助30
45秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531910
关于积分的说明 11255394
捐赠科研通 3270563
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882157
科研通“疑难数据库(出版商)”最低求助积分说明 809190