一氧化氮
促炎细胞因子
血脑屏障
神经保护
膜
S-亚硝基谷胱甘肽
化学
纳米技术
材料科学
生物物理学
药理学
炎症
医学
中枢神经系统
生物化学
免疫学
生物
内科学
谷胱甘肽
酶
作者
Zhixin Huang,Binbin Hu,Bohan Xiang,Huaqiang Fang,Bingzhen Zhang,Ying Wang,Yi Zhuo,Dan Deng,Xiaolei Wang
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2023-04-11
卷期号:9 (5): 2545-2557
被引量:6
标识
DOI:10.1021/acsbiomaterials.3c00146
摘要
The existence of the blood–brain barrier (BBB) and the complex inflammatory environment in the brain are two major obstacles in the treatment of Parkinson's disease (PD). As a target group, we modified the red blood cell membrane (RBCM) on the surface of upconversion nanoparticles (UCNPs) in this study to effectively target the brain. Mesoporous silicon, coated with UCNPs (UCM), was loaded with S-nitrosoglutathione (GSNO) as the nitric oxide (NO) donor. Then, UCNPs were excited to emit green light (540 nm) by 980 nm near-infrared (NIR). In addition, it produced a light-responsive anti-inflammatory effect by promoting the release of NO from GSNO and lowering the brain's level of proinflammatory factors. A series of experiments demonstrated that this strategy could effectively mitigate the inflammatory response damage of neurons in the brain.
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