Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

Mixed signals: The glycophospholipid 1, consisting of two cholinylphospho-GalNAc units, two 2-acetamino-4-amino-2,4,6-trideoxygalactose rings, three glucose residues each with different linkages to other sugar units, and a ribitolphosphate residue, has been synthesized. Target 1 is recognized by the immune system, but not by the TLR-2 signaling receptor as previously postulated. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.