On the risk of secondary cancer from thymoma radiotherapy

医学 放射治疗 核医学 胸腺瘤 放射治疗计划 热释光剂量计 癌症 剂量计 放射科 外科 剂量学 内科学
作者
Wassim Jalbout,Rania Jbara,Chadia Rizk,Bassem Youssef
出处
期刊:Physics in Medicine and Biology [IOP Publishing]
卷期号:67 (15): 155015-155015 被引量:2
标识
DOI:10.1088/1361-6560/ac7c50
摘要

Abstract Objective. This study aims at quantifying the lifetime attributable risk of secondary fatal cancer (LARFAC) to patients receiving adjuvant radiotherapy treatment for thymoma, a neoplasm where cure rates and life expectancy are relatively high, patient age at presentation relatively low and indications for radiotherapy controversial depending on the disease stage. Approach. An anthropomorphic phantom was scanned, organs were contoured and a standard 6 MV 3DCRT treatment plan was produced for thymoma treatment. The phantom was loaded with thermoluminescent dosimeters (TLDs) and treated by linear accelerator per plan. The TLDs were subsequently read for out-of-field dose distribution while in-field dose distribution was obtained from the planning system. Sex and age-specific lifetime radiogenic cancer risk was calculated as the sum of in-field risk and out-of-field risk. The latter risk was estimated using hybrid ICRP 2007 103-BEIR VII tables of organ-specific risks based on the linear-no threshold (LNT) model and applicable at low doses, while the former using mathematical risk models applicable at high doses. Main results. The LARFAC associated with a prescribed dose of 50 Gy to target volume in 25 fractions was in the approximate range of 1%–3%. The risk was higher for young and female patients. The largest contributing organ to this risk were the lungs by far. Using the LNT model inappropriately to calculate risk at therapeutic doses (in-field) would overestimate the risk up to tenfold. Significance. The LARFAC to patient from thymoma radiotherapy was quantified taking into consideration the inapplicability of the LNT model at therapeutic doses. The risk is not negligible; the information may be relevant to patients and clinicians.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Xiao完成签到,获得积分10
刚刚
Hh完成签到,获得积分10
1秒前
1秒前
1秒前
1秒前
FLZLC应助kkkkkkk_采纳,获得20
2秒前
2秒前
科研通AI2S应助迅速珩采纳,获得10
2秒前
2秒前
万能图书馆应助Mr_W采纳,获得10
3秒前
真金小子完成签到 ,获得积分10
4秒前
银海里的玫瑰_完成签到 ,获得积分10
4秒前
David发布了新的文献求助10
5秒前
善良夜梅发布了新的文献求助20
5秒前
6秒前
knn完成签到 ,获得积分10
6秒前
7秒前
Yippee完成签到,获得积分10
8秒前
zhang完成签到,获得积分10
8秒前
专注寻菱完成签到,获得积分10
9秒前
Jasen完成签到 ,获得积分10
9秒前
机会啊完成签到,获得积分10
10秒前
繁荣的映雁完成签到,获得积分10
10秒前
11秒前
11秒前
可爱的函函应助drughunter009采纳,获得10
12秒前
务实的绝悟完成签到,获得积分10
13秒前
13秒前
14秒前
专注的树完成签到,获得积分10
14秒前
14秒前
14秒前
顺利白竹完成签到 ,获得积分10
15秒前
xfwang发布了新的文献求助10
15秒前
Peak发布了新的文献求助10
16秒前
Joker完成签到,获得积分10
16秒前
Juniper完成签到 ,获得积分10
16秒前
彭于晏应助石语芙采纳,获得10
16秒前
David完成签到,获得积分10
16秒前
wangtingyu完成签到,获得积分10
16秒前
高分求助中
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Barge Mooring (Oilfield Seamanship Series Volume 6) 600
ANSYS Workbench基础教程与实例详解 500
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3326918
求助须知:如何正确求助?哪些是违规求助? 2957197
关于积分的说明 8583900
捐赠科研通 2635137
什么是DOI,文献DOI怎么找? 1442366
科研通“疑难数据库(出版商)”最低求助积分说明 668210
邀请新用户注册赠送积分活动 655109