Association of exposure to ambient particulate matter with maternal thyroid function in early pregnancy

怀孕 医学 甲状腺功能 环境化学 甲状腺 微粒 内科学 生理学 环境卫生 化学 生物 遗传学 有机化学
作者
Xichi Zhang,Anke Hüls,Robert W. Makuch,Aifen Zhou,Tao Zheng,Wei Xia,Audrey J. Gaskins,Jad Makuch,Zhou Zhu,Cairong Zhu,Zhengmin Qian,Shunqing Xu,Yuanyuan Li
出处
期刊:Environmental Research [Elsevier BV]
卷期号:214: 113942-113942 被引量:4
标识
DOI:10.1016/j.envres.2022.113942
摘要

It is known that maternal thyroid dysfunction during early pregnancy can cause adverse pregnancy complications and birth outcomes. This study was designed to examine the association between ambient particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) and particulate matter with aerodynamic diameters ≤10 μm (PM10) exposure and maternal thyroid function during early pregnancy.This study was based on data from a birth cohort study of 921 pregnant women in China. We estimated associations between ambient PM2.5 and PM10 exposure during the first trimester of pregnancy (estimated with land-use regression models) and maternal thyroid hormone concentrations (free thyroxine (FT4), free tri-iodothyronine (FT3), and thyroid-stimulating hormone (TSH)) collected between weeks 10 and 17 of gestation using linear regression models adjusting for potential confounders. Ambient PM2.5 and PM10 concentrations were modeled per interquartile range (IQR) increment and as tertiles based on the distribution of the exposure levels.An IQR increment (68 μg/m3) in PM2.5 exposure was associated with a significant decrease in maternal FT4 levels (β = -0.60, 95% CI: -1.07, -0.12); and a significant decrease in FT4/FT3 ratio (β = -0.13, 95% CI: -0.25, -0.02). Further analyses showed that, relative to the lowest tertile, women in both the middle and highest tertiles of PM2.5 had significantly lower concentrations of maternal FT4 and FT4/FT3 ratio. No significant associations were found between PM2.5 and FT3 or TSH levels. PM10 exposure was not significantly associated with maternal thyroid function.Our study suggested that higher ambient PM2.5, not PM10, exposed during the first trimester of pregnancy were associated with a significant decrease in maternal serum FT4 concentrations and FT4/FT3 ratio. Studies in populations with different exposure levels are needed to replicate our study results.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
3秒前
吧唧一笑的go关注了科研通微信公众号
5秒前
WangXinkui完成签到,获得积分10
7秒前
东耦完成签到,获得积分10
7秒前
8秒前
hbutsj完成签到,获得积分10
10秒前
KK完成签到,获得积分10
12秒前
careyzhou发布了新的文献求助10
13秒前
中原第一深情完成签到,获得积分10
13秒前
小洪俊熙发布了新的文献求助10
14秒前
北望完成签到,获得积分20
14秒前
Lee完成签到 ,获得积分10
15秒前
科研狗完成签到 ,获得积分10
16秒前
量子星尘发布了新的文献求助10
18秒前
18秒前
romeo发布了新的文献求助10
21秒前
妖孽宇完成签到,获得积分10
23秒前
简简单单完成签到,获得积分10
23秒前
550190946发布了新的文献求助10
23秒前
25秒前
111完成签到,获得积分10
25秒前
zhubin完成签到 ,获得积分10
25秒前
27秒前
田南松发布了新的文献求助10
30秒前
搬砖美少女完成签到,获得积分10
30秒前
nn发布了新的文献求助10
31秒前
7ohnny完成签到,获得积分10
32秒前
apckkk完成签到 ,获得积分10
34秒前
深情安青应助550190946采纳,获得10
35秒前
36秒前
37秒前
jbq完成签到 ,获得积分20
37秒前
YM完成签到,获得积分10
39秒前
生动柔发布了新的文献求助10
39秒前
大旭完成签到 ,获得积分10
40秒前
Fn完成签到 ,获得积分10
42秒前
zero完成签到,获得积分10
44秒前
瘦瘦谷兰完成签到,获得积分10
44秒前
zcz完成签到 ,获得积分10
45秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022