Role of molecularly imprinted hydrogels in drug delivery - A current perspective

Molecular imprinting in hydrogels crafts memory for template molecules in a flexible macromolecular structure. Molecular imprinting can control the pattern of the drug release via different mechanistic pathways which may involve swelling, which releases the drug via diffusion or receptive-swollen networks. Responsive hydrogels or smart hydrogels can be tailored to undergo a change in the network structure in response to a stimulus by inserting specific chemical or biological entities along their backbone polymer chains. The stimuli which can be either physical, chemical or biochemical in nature, may impact at various energy levels thereby initiating the molecular interactions at critical onset points. Conventional hydrogels lack in responding to an external stimuli in a swift manner, hence the molecular imprinting technology can significantly advance the therapeutic efficiency of the drugs with anticipated controlled release and targeting efficiency. Molecular imprinting in hydrogels is thus anticipated as a step towards establishment of drug delivery systems by providing improved delivery profiles or longer release times and deliver the drugs in a feedback regulated way. The review article focuses on the current scenario of molecularly imprinted hydrogels with emphasis on the imprinting strategies within hydrogels and challenges encountered, latent translational applications, and future perspectives.