Part I: Epidemiology, pathophysiology, and clinical considerations of primary and secondary Raynaud's phenomenon

医学 流行病学 皮肤病科 结缔组织病 疾病 病理生理学 发病机制 结缔组织 介绍(产科) 病理 重症监护医学 自身免疫性疾病 外科
作者
Paul H. Curtiss,Katerina Svigos,Zachary Schwager,Kristen Lo Sicco,Andrew G Franks
出处
期刊:Journal of The American Academy of Dermatology [Elsevier]
卷期号:90 (2): 223-234 被引量:7
标识
DOI:10.1016/j.jaad.2022.06.1199
摘要

Raynaud's phenomenon (RP) is a relatively common disease with both primary and secondary forms. It is well understood as a vasospastic condition affecting the acral and digital arteries, resulting in characteristic, well-demarcated color changes typically in the hands and feet in response to cold or stress. Secondary RP (SRP) has been described in association with a variety of rheumatologic and nonrheumatologic diseases, environmental exposures, and/or medications. While both primary RP and SRP may impact the quality of life, SRP may lead to permanent and potentially devastating tissue destruction when undiagnosed and untreated. It is therefore crucial for dermatologists to distinguish between primary and secondary disease forms early in clinical evaluation, investigate potential underlying causes, and risk stratify SRP patients for the development of associated autoimmune connective tissue disease. The epidemiology, pathogenesis, and clinical presentation and diagnosis of both forms of RP are described in detail in this review article. Raynaud's phenomenon (RP) is a relatively common disease with both primary and secondary forms. It is well understood as a vasospastic condition affecting the acral and digital arteries, resulting in characteristic, well-demarcated color changes typically in the hands and feet in response to cold or stress. Secondary RP (SRP) has been described in association with a variety of rheumatologic and nonrheumatologic diseases, environmental exposures, and/or medications. While both primary RP and SRP may impact the quality of life, SRP may lead to permanent and potentially devastating tissue destruction when undiagnosed and untreated. It is therefore crucial for dermatologists to distinguish between primary and secondary disease forms early in clinical evaluation, investigate potential underlying causes, and risk stratify SRP patients for the development of associated autoimmune connective tissue disease. The epidemiology, pathogenesis, and clinical presentation and diagnosis of both forms of RP are described in detail in this review article. Part II: The treatment of primary and secondary Raynaud's phenomenonJournal of the American Academy of DermatologyVol. 90Issue 2PreviewRaynaud phenomenon (RP) presents with either primary or secondary disease, and both have the potential to negatively impact patient quality of life. First-line management of RP should include lifestyle modifications in all patients. Some patients with primary RP and most with secondary RP require pharmacologic therapies, which may include calcium channel blockers, topical nitrates, phosphodiesterase 5 inhibitors, or endothelin antagonists. Additional approaches to treatment for those with signs of critical ischemia or those who fail pharmacologic therapy include botulinum toxin injection and digital sympathectomy. Full-Text PDF Journal based CME instructions and informationJournal of the American Academy of DermatologyVol. 90Issue 2Preview Full-Text PDF CME examinationJournal of the American Academy of DermatologyVol. 90Issue 2Preview Full-Text PDF
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