表观遗传学
染色质
生物
DNA甲基化
组蛋白
计算生物学
表观遗传学
增强子
转录组
遗传学
基因表达调控
基因组学
表观基因组
基因
基因组
转录因子
基因表达
作者
Sebastian Preißl,Kyle J. Gaulton,Bing Ren
标识
DOI:10.1038/s41576-022-00509-1
摘要
Cell type-specific gene expression patterns and dynamics during development or in disease are controlled by cis-regulatory elements (CREs), such as promoters and enhancers. Distinct classes of CREs can be characterized by their epigenomic features, including DNA methylation, chromatin accessibility, combinations of histone modifications and conformation of local chromatin. Tremendous progress has been made in cataloguing CREs in the human genome using bulk transcriptomic and epigenomic methods. However, single-cell epigenomic and multi-omic technologies have the potential to provide deeper insight into cell type-specific gene regulatory programmes as well as into how they change during development, in response to environmental cues and through disease pathogenesis. Here, we highlight recent advances in single-cell epigenomic methods and analytical tools and discuss their readiness for human tissue profiling.
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