The effect of clinical pharmacists’ intervention in adverse drug reaction reporting: a retrospective analysis with a 9-year interrupted time series

医学 中断时间序列分析 中断时间序列 临床药学 干预(咨询) 毒品类别 急诊医学 卫生行政 药物反应 药物不良反应 公共卫生 药品 儿科 医疗急救 家庭医学 药店 心理干预 药理学 护理部 统计 数学
作者
Tianwei Lan,Hua Wang,Xin Li,Hang Yin,Dan Shao,Yueyao Jiang,Qian Yu
出处
期刊:BMC Health Services Research [BioMed Central]
卷期号:22 (1) 被引量:1
标识
DOI:10.1186/s12913-022-08320-8
摘要

In China, 85.4% of adverse drug reactions (ADRs) are spontaneously reported by healthcare facilities. As a result, many ADRs are not reported due to lack of mandatory reporting requirements. As healthcare professionals, clinical pharmacists (CPhs) serve as a bridge between clinical work and medication and ensure rational drug use. In China, A team of CPhs implemented an intervention for ADRs reporting, with the goal of improving the number of ADRs reports, the number of unreported ADRs, and the standardized reporting rate.On June 01, 2015, a team of CPhs implemented an intervention for ADRs reporting at a Grade A, Class 3 hospital in China. The drug review catalogue (DRC) was used to screen physician orders for having visible symptoms of ADRs across departments, pooled the ADRs, and submitted them to the Center for Advanced Drug Monitoring (CNCAM). We retrospectively analysed the effect of a CPhs ADRs reporting intervention on the number of clinical ADRs reports, the number of unreported ADRs, and the standardized reporting rate over a 9-year period by interrupted time series (ITS). The method was implemented at the hospital on June 1, 2015, and a segmented regression model was used to analyse the data from January 1, 2010, to December 31, 2019.After the CPhs ADRs reporting intervention, the number of inpatient ADRs reports submitted to the CNCAM immediately increased by approximately 63 (62.658, P < 0.01) and then decreased by approximately 1 (0.701, P = 0.000151 < 0.01) per month afterward; the number of unreported ADRs was immediately reduced by approximately 44 (44.091, P < 0.01) and remained largely unchanged over time (P > 0.05); the standardized ADRs reporting rate per month immediately increased by 63.634% (P < 0.01) and remained largely unchanged over time (P > 0.05).The CPhs ADRs reporting intervention had an immediate effect on improving ADRs reporting, which highlights the severity of ADRs underreporting in Chinese hospitals. The method is practical and should be used more widely in clinical practice. For example, the method can adjust and establish a DRC catalog that meets the actual situation of the implementing hospital based on the hospital's drug use habits and has the characteristics of good adaptability. However, it does have some limitations; for example, it may be difficult to detect early ADRs without visible symptoms.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
NiNi完成签到,获得积分10
1秒前
Ther完成签到,获得积分20
2秒前
傲娇白安完成签到,获得积分10
3秒前
3秒前
甜蜜的荟完成签到,获得积分20
4秒前
婷儿完成签到,获得积分10
4秒前
牛牛发布了新的文献求助10
4秒前
Hoper完成签到,获得积分10
4秒前
张曰淼完成签到,获得积分10
5秒前
共渡完成签到,获得积分10
7秒前
凉白开完成签到 ,获得积分10
8秒前
跳跃的太君完成签到,获得积分10
9秒前
小猪发布了新的文献求助10
9秒前
独特问夏完成签到,获得积分10
10秒前
10秒前
11秒前
魔幻蓉完成签到,获得积分10
11秒前
杠赛来完成签到,获得积分10
11秒前
ccy完成签到 ,获得积分10
12秒前
Ch185完成签到,获得积分10
13秒前
欣喜的复天完成签到,获得积分10
15秒前
摸鱼校尉完成签到,获得积分0
15秒前
双儿完成签到,获得积分10
15秒前
顺利毕业完成签到 ,获得积分10
15秒前
儒雅的焦完成签到 ,获得积分10
15秒前
小何完成签到 ,获得积分10
15秒前
17秒前
18秒前
小曾应助张绪帆采纳,获得10
18秒前
麻麻薯完成签到 ,获得积分10
19秒前
19秒前
Smes完成签到,获得积分10
19秒前
王金豪发布了新的文献求助10
20秒前
勤劳冰烟完成签到,获得积分10
20秒前
顺顺尼完成签到 ,获得积分10
21秒前
22秒前
阿曾发布了新的文献求助10
23秒前
23秒前
鹤昀完成签到 ,获得积分10
24秒前
lenaimiao完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029